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Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk

AIMS/HYPOTHESIS: Translation of genetic association signals into molecular mechanisms for diabetes has been slow. The glucokinase regulatory protein (GKRP; gene symbol GCKR) P446L variant, associated with inverse modulation of glucose- and lipid-related traits, has been shown to alter the kinetics o...

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Detalles Bibliográficos
Autores principales:	Rees, M. G., Wincovitch, S., Schultz, J., Waterstradt, R., Beer, N. L., Baltrusch, S., Collins, F. S., Gloyn, A. L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276843/ https://www.ncbi.nlm.nih.gov/pubmed/22038520 http://dx.doi.org/10.1007/s00125-011-2348-5

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