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CONGENITAL LUPUS ERYTHEMATOSUS
Neonatal lupus erythematosus (NLE) is an autoimmune disease affecting the fetus as a result of transplacental transfer of anti-Ro autoantibodies. Typically, it presents in the first few months of life with an annular form of subacute cutaneous lupus erythematosus. We report an unusual case of NLE pr...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276909/ https://www.ncbi.nlm.nih.gov/pubmed/22345783 http://dx.doi.org/10.4103/0019-5154.91841 |
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author | Bhatt, Taseer Ahmed Fatani, Hanadi A Mimesh, Samara |
author_facet | Bhatt, Taseer Ahmed Fatani, Hanadi A Mimesh, Samara |
author_sort | Bhatt, Taseer Ahmed |
collection | PubMed |
description | Neonatal lupus erythematosus (NLE) is an autoimmune disease affecting the fetus as a result of transplacental transfer of anti-Ro autoantibodies. Typically, it presents in the first few months of life with an annular form of subacute cutaneous lupus erythematosus. We report an unusual case of NLE presenting at birth with scaly erythematous telangiectatic patches and macules with skin atrophy involving the face, head, and upper trunk. Thrombocytopenia was discovered on laboratory investigations. Histopathology of skin biopsy was consistent with subacute cutaneous lupus. The mother was clinically free of disease and had no family history of autoimmune disease. Serology (extra-nuclear antigens) was positive in both the baby and the mother. This is a rare presentation of a rare disease. |
format | Online Article Text |
id | pubmed-3276909 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-32769092012-02-16 CONGENITAL LUPUS ERYTHEMATOSUS Bhatt, Taseer Ahmed Fatani, Hanadi A Mimesh, Samara Indian J Dermatol Case Report Neonatal lupus erythematosus (NLE) is an autoimmune disease affecting the fetus as a result of transplacental transfer of anti-Ro autoantibodies. Typically, it presents in the first few months of life with an annular form of subacute cutaneous lupus erythematosus. We report an unusual case of NLE presenting at birth with scaly erythematous telangiectatic patches and macules with skin atrophy involving the face, head, and upper trunk. Thrombocytopenia was discovered on laboratory investigations. Histopathology of skin biopsy was consistent with subacute cutaneous lupus. The mother was clinically free of disease and had no family history of autoimmune disease. Serology (extra-nuclear antigens) was positive in both the baby and the mother. This is a rare presentation of a rare disease. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3276909/ /pubmed/22345783 http://dx.doi.org/10.4103/0019-5154.91841 Text en Copyright: © Indian Journal of Dermatology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Bhatt, Taseer Ahmed Fatani, Hanadi A Mimesh, Samara CONGENITAL LUPUS ERYTHEMATOSUS |
title | CONGENITAL LUPUS ERYTHEMATOSUS |
title_full | CONGENITAL LUPUS ERYTHEMATOSUS |
title_fullStr | CONGENITAL LUPUS ERYTHEMATOSUS |
title_full_unstemmed | CONGENITAL LUPUS ERYTHEMATOSUS |
title_short | CONGENITAL LUPUS ERYTHEMATOSUS |
title_sort | congenital lupus erythematosus |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276909/ https://www.ncbi.nlm.nih.gov/pubmed/22345783 http://dx.doi.org/10.4103/0019-5154.91841 |
work_keys_str_mv | AT bhatttaseerahmed congenitallupuserythematosus AT fatanihanadia congenitallupuserythematosus AT mimeshsamara congenitallupuserythematosus |