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POOR NEUROLOGICAL SEQUELAE OF HERPES SIMPLEX VIRUS ENCEPHALITIS IN AN INFANT DESPITE ADEQUATE ANTIVIRAL AND ADJUNCT CORTICOSTEROID THERAPY
A 2-month-old infant presented to our emergency department with fever, altered consciousness, and focal seizures of acute onset. He had vesicular skin lesions over the right preauricular region. CT brain showed a large hypodense lesion involving the left temporo-parietal region, left basal ganglia a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276914/ https://www.ncbi.nlm.nih.gov/pubmed/22345788 http://dx.doi.org/10.4103/0019-5154.91846 |
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author | Basak, Ratna B Malpani, Varsha Kakish, Khalid Vargese, Susan Chauhan, Nageshwar Boeck, Andreas |
author_facet | Basak, Ratna B Malpani, Varsha Kakish, Khalid Vargese, Susan Chauhan, Nageshwar Boeck, Andreas |
author_sort | Basak, Ratna B |
collection | PubMed |
description | A 2-month-old infant presented to our emergency department with fever, altered consciousness, and focal seizures of acute onset. He had vesicular skin lesions over the right preauricular region. CT brain showed a large hypodense lesion involving the left temporo-parietal region, left basal ganglia and left thalamus. MRI brain revealed bilateral multifocal corticomedullary lesions suggestive of encephalitis. CSF-PCR was positive for herpes simplex virus (HSV) type I. He was treated with standard dose intravenous acyclovir for 15 days along with a trial of pulse methylprednisolone, but was readmitted within a week with features of an early relapse. The infant survived but developed significant neurological sequelae. Although treatment of HSV is available, the neurological outcome is guarded even with adequate antiviral therapy. Adjunct corticosteroid therapy did not appear to attenuate the neurological sequelae. |
format | Online Article Text |
id | pubmed-3276914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-32769142012-02-16 POOR NEUROLOGICAL SEQUELAE OF HERPES SIMPLEX VIRUS ENCEPHALITIS IN AN INFANT DESPITE ADEQUATE ANTIVIRAL AND ADJUNCT CORTICOSTEROID THERAPY Basak, Ratna B Malpani, Varsha Kakish, Khalid Vargese, Susan Chauhan, Nageshwar Boeck, Andreas Indian J Dermatol Case Report A 2-month-old infant presented to our emergency department with fever, altered consciousness, and focal seizures of acute onset. He had vesicular skin lesions over the right preauricular region. CT brain showed a large hypodense lesion involving the left temporo-parietal region, left basal ganglia and left thalamus. MRI brain revealed bilateral multifocal corticomedullary lesions suggestive of encephalitis. CSF-PCR was positive for herpes simplex virus (HSV) type I. He was treated with standard dose intravenous acyclovir for 15 days along with a trial of pulse methylprednisolone, but was readmitted within a week with features of an early relapse. The infant survived but developed significant neurological sequelae. Although treatment of HSV is available, the neurological outcome is guarded even with adequate antiviral therapy. Adjunct corticosteroid therapy did not appear to attenuate the neurological sequelae. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3276914/ /pubmed/22345788 http://dx.doi.org/10.4103/0019-5154.91846 Text en Copyright: © Indian Journal of Dermatology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Basak, Ratna B Malpani, Varsha Kakish, Khalid Vargese, Susan Chauhan, Nageshwar Boeck, Andreas POOR NEUROLOGICAL SEQUELAE OF HERPES SIMPLEX VIRUS ENCEPHALITIS IN AN INFANT DESPITE ADEQUATE ANTIVIRAL AND ADJUNCT CORTICOSTEROID THERAPY |
title | POOR NEUROLOGICAL SEQUELAE OF HERPES SIMPLEX VIRUS ENCEPHALITIS IN AN INFANT DESPITE ADEQUATE ANTIVIRAL AND ADJUNCT CORTICOSTEROID THERAPY |
title_full | POOR NEUROLOGICAL SEQUELAE OF HERPES SIMPLEX VIRUS ENCEPHALITIS IN AN INFANT DESPITE ADEQUATE ANTIVIRAL AND ADJUNCT CORTICOSTEROID THERAPY |
title_fullStr | POOR NEUROLOGICAL SEQUELAE OF HERPES SIMPLEX VIRUS ENCEPHALITIS IN AN INFANT DESPITE ADEQUATE ANTIVIRAL AND ADJUNCT CORTICOSTEROID THERAPY |
title_full_unstemmed | POOR NEUROLOGICAL SEQUELAE OF HERPES SIMPLEX VIRUS ENCEPHALITIS IN AN INFANT DESPITE ADEQUATE ANTIVIRAL AND ADJUNCT CORTICOSTEROID THERAPY |
title_short | POOR NEUROLOGICAL SEQUELAE OF HERPES SIMPLEX VIRUS ENCEPHALITIS IN AN INFANT DESPITE ADEQUATE ANTIVIRAL AND ADJUNCT CORTICOSTEROID THERAPY |
title_sort | poor neurological sequelae of herpes simplex virus encephalitis in an infant despite adequate antiviral and adjunct corticosteroid therapy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276914/ https://www.ncbi.nlm.nih.gov/pubmed/22345788 http://dx.doi.org/10.4103/0019-5154.91846 |
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