Acute promyelocytic leukemia with unusual karyotype

Acute myeloid leukemia (AML-M3) is associated with the translocation t(15;17)(q22;q12-21) which disrupts the retinoic acid receptor alpha (RARA) gene on chromosome 17 and the PML gene on chromosome 15. We report a two-year-old patient with AML-M3 without the usual translocation t(15;17). Cytogenetic...

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Autores principales: Gowri, Mangala, Jahan, S. K. Kousar, Kavitha, Prasannakumari, Madhumathi, Appaji, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276997/
https://www.ncbi.nlm.nih.gov/pubmed/22346000
http://dx.doi.org/10.4103/0971-6866.92093
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author Gowri, Mangala
Jahan, S. K. Kousar
Kavitha,
Prasannakumari,
Madhumathi,
Appaji, L.
author_facet Gowri, Mangala
Jahan, S. K. Kousar
Kavitha,
Prasannakumari,
Madhumathi,
Appaji, L.
author_sort Gowri, Mangala
collection PubMed
description Acute myeloid leukemia (AML-M3) is associated with the translocation t(15;17)(q22;q12-21) which disrupts the retinoic acid receptor alpha (RARA) gene on chromosome 17 and the PML gene on chromosome 15. We report a two-year-old patient with AML-M3 without the usual translocation t(15;17). Cytogenetic studies demonstrated normal appearance of chromosome 15 while the abnormal 17 homologue was apparently a derivative 17, der(17)(17qter-cen-q21:), the rearrangement distinctly shows deletion at 17q21 band and the morphology corresponding to an iso chromosome i(17q-). This case report is a rare cytogenetic presentation of acute promyelocytic leukemia (APML).
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spelling pubmed-32769972012-02-16 Acute promyelocytic leukemia with unusual karyotype Gowri, Mangala Jahan, S. K. Kousar Kavitha, Prasannakumari, Madhumathi, Appaji, L. Indian J Hum Genet Case Report Acute myeloid leukemia (AML-M3) is associated with the translocation t(15;17)(q22;q12-21) which disrupts the retinoic acid receptor alpha (RARA) gene on chromosome 17 and the PML gene on chromosome 15. We report a two-year-old patient with AML-M3 without the usual translocation t(15;17). Cytogenetic studies demonstrated normal appearance of chromosome 15 while the abnormal 17 homologue was apparently a derivative 17, der(17)(17qter-cen-q21:), the rearrangement distinctly shows deletion at 17q21 band and the morphology corresponding to an iso chromosome i(17q-). This case report is a rare cytogenetic presentation of acute promyelocytic leukemia (APML). Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3276997/ /pubmed/22346000 http://dx.doi.org/10.4103/0971-6866.92093 Text en Copyright: © Indian Journal of Human Genetics http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Gowri, Mangala
Jahan, S. K. Kousar
Kavitha,
Prasannakumari,
Madhumathi,
Appaji, L.
Acute promyelocytic leukemia with unusual karyotype
title Acute promyelocytic leukemia with unusual karyotype
title_full Acute promyelocytic leukemia with unusual karyotype
title_fullStr Acute promyelocytic leukemia with unusual karyotype
title_full_unstemmed Acute promyelocytic leukemia with unusual karyotype
title_short Acute promyelocytic leukemia with unusual karyotype
title_sort acute promyelocytic leukemia with unusual karyotype
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276997/
https://www.ncbi.nlm.nih.gov/pubmed/22346000
http://dx.doi.org/10.4103/0971-6866.92093
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