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Study of the association between –403G/A and –28C/G RANTES gene polymorphisms and asthma in Lebanon

CONTEXT: Asthma is a complex inflammatory condition often associated with bronchial hyper reactivity and atopy. Genetic and environmental factors are implicated in the etiopathogenesis of asthma. Regulated upon Activation Normal T- cell Expressed and Secreted (RANTES) is a CC chemokine responsible f...

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Autores principales: Nahas, Rana, Fakhoury, Hana M., Chmaisse, Hania N., Makki, Rajaa F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277035/
https://www.ncbi.nlm.nih.gov/pubmed/22347345
http://dx.doi.org/10.4103/1817-1737.91558
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author Nahas, Rana
Fakhoury, Hana M.
Chmaisse, Hania N.
Makki, Rajaa F.
author_facet Nahas, Rana
Fakhoury, Hana M.
Chmaisse, Hania N.
Makki, Rajaa F.
author_sort Nahas, Rana
collection PubMed
description CONTEXT: Asthma is a complex inflammatory condition often associated with bronchial hyper reactivity and atopy. Genetic and environmental factors are implicated in the etiopathogenesis of asthma. Regulated upon Activation Normal T- cell Expressed and Secreted (RANTES) is a CC chemokine responsible for the recruitment of inflammatory cells, suggesting a possible role for this chemokine in asthma. Both -403A and -28G alleles of the RANTES promoter region were found to be associated with asthma/atopy in some but not all studies. AIM: The purpose of this study was to investigate the genetic influence of -403A and -28G alleles of the RANTES promoter region on the development of asthma in Lebanon. SETTINGS AND DESIGN: This case control study was conducted at Makassed Hospital, Beirut on 40 asthmatic patients and 38 healthy controls. METHODS: RANTES gene polymorphisms -403G/A and -28C/G alleles were genotyped using PCR-RFLP. RESULTS: No significant differences in allele or genotype frequencies for the RANTES gene polymorphisms between asthmatic patients and controls were found. The difference of the -403 GA genotype frequency between patients and controls was not statisti-cally significant; (OR=0.8, 95% CI=0.2-2.3, P=0.8). Similarly, the difference of the A-allele frequencies between patients and con-trols was not significant (OR=0.824, CI=0.3–2.2, P=0.7). CONCLUSIONS: Our data show that RANTES gene promoter polymorphisms are not associated with asthma susceptibility in the Lebanese population.
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spelling pubmed-32770352012-02-16 Study of the association between –403G/A and –28C/G RANTES gene polymorphisms and asthma in Lebanon Nahas, Rana Fakhoury, Hana M. Chmaisse, Hania N. Makki, Rajaa F. Ann Thorac Med Original Article CONTEXT: Asthma is a complex inflammatory condition often associated with bronchial hyper reactivity and atopy. Genetic and environmental factors are implicated in the etiopathogenesis of asthma. Regulated upon Activation Normal T- cell Expressed and Secreted (RANTES) is a CC chemokine responsible for the recruitment of inflammatory cells, suggesting a possible role for this chemokine in asthma. Both -403A and -28G alleles of the RANTES promoter region were found to be associated with asthma/atopy in some but not all studies. AIM: The purpose of this study was to investigate the genetic influence of -403A and -28G alleles of the RANTES promoter region on the development of asthma in Lebanon. SETTINGS AND DESIGN: This case control study was conducted at Makassed Hospital, Beirut on 40 asthmatic patients and 38 healthy controls. METHODS: RANTES gene polymorphisms -403G/A and -28C/G alleles were genotyped using PCR-RFLP. RESULTS: No significant differences in allele or genotype frequencies for the RANTES gene polymorphisms between asthmatic patients and controls were found. The difference of the -403 GA genotype frequency between patients and controls was not statisti-cally significant; (OR=0.8, 95% CI=0.2-2.3, P=0.8). Similarly, the difference of the A-allele frequencies between patients and con-trols was not significant (OR=0.824, CI=0.3–2.2, P=0.7). CONCLUSIONS: Our data show that RANTES gene promoter polymorphisms are not associated with asthma susceptibility in the Lebanese population. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3277035/ /pubmed/22347345 http://dx.doi.org/10.4103/1817-1737.91558 Text en Copyright: © Annals of Thoracic Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Nahas, Rana
Fakhoury, Hana M.
Chmaisse, Hania N.
Makki, Rajaa F.
Study of the association between –403G/A and –28C/G RANTES gene polymorphisms and asthma in Lebanon
title Study of the association between –403G/A and –28C/G RANTES gene polymorphisms and asthma in Lebanon
title_full Study of the association between –403G/A and –28C/G RANTES gene polymorphisms and asthma in Lebanon
title_fullStr Study of the association between –403G/A and –28C/G RANTES gene polymorphisms and asthma in Lebanon
title_full_unstemmed Study of the association between –403G/A and –28C/G RANTES gene polymorphisms and asthma in Lebanon
title_short Study of the association between –403G/A and –28C/G RANTES gene polymorphisms and asthma in Lebanon
title_sort study of the association between –403g/a and –28c/g rantes gene polymorphisms and asthma in lebanon
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277035/
https://www.ncbi.nlm.nih.gov/pubmed/22347345
http://dx.doi.org/10.4103/1817-1737.91558
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