Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease

An association between a rare, coding, non-synonymous SNP variant in the gene DZIP1 and Parkinson's disease was found, based on an analysis of the existing NGRC genome-wide association study dataset. The statistical analysis utilized the hypothesis-rich, targeted search unbiased assessment appr...

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Autores principales: Valente, André X. C. N., Shin, Joo H., Sarkar, Abhijit, Gao, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277088/
https://www.ncbi.nlm.nih.gov/pubmed/22355768
http://dx.doi.org/10.1038/srep00256
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author Valente, André X. C. N.
Shin, Joo H.
Sarkar, Abhijit
Gao, Yuan
author_facet Valente, André X. C. N.
Shin, Joo H.
Sarkar, Abhijit
Gao, Yuan
author_sort Valente, André X. C. N.
collection PubMed
description An association between a rare, coding, non-synonymous SNP variant in the gene DZIP1 and Parkinson's disease was found, based on an analysis of the existing NGRC genome-wide association study dataset. The statistical analysis utilized the hypothesis-rich, targeted search unbiased assessment approach, rather than the hypothesis-free, genome-wide agnostic search paradigm. The association of DZIP1 with Parkinson's disease is discussed in the context of a Parkinson's disease stem-cell ageing theory.
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spelling pubmed-32770882012-02-10 Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease Valente, André X. C. N. Shin, Joo H. Sarkar, Abhijit Gao, Yuan Sci Rep Article An association between a rare, coding, non-synonymous SNP variant in the gene DZIP1 and Parkinson's disease was found, based on an analysis of the existing NGRC genome-wide association study dataset. The statistical analysis utilized the hypothesis-rich, targeted search unbiased assessment approach, rather than the hypothesis-free, genome-wide agnostic search paradigm. The association of DZIP1 with Parkinson's disease is discussed in the context of a Parkinson's disease stem-cell ageing theory. Nature Publishing Group 2012-02-10 /pmc/articles/PMC3277088/ /pubmed/22355768 http://dx.doi.org/10.1038/srep00256 Text en Copyright © 2012, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Article
Valente, André X. C. N.
Shin, Joo H.
Sarkar, Abhijit
Gao, Yuan
Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease
title Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease
title_full Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease
title_fullStr Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease
title_full_unstemmed Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease
title_short Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease
title_sort rare coding snp in dzip1 gene associated with late-onset sporadic parkinson's disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277088/
https://www.ncbi.nlm.nih.gov/pubmed/22355768
http://dx.doi.org/10.1038/srep00256
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