Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization

Recently we reported that the BH3-only proteins Bim and Noxa bind tightly but transiently to the BH3-binding groove of Bak to initiate Bak homo-oligomerization. However, it is unclear how such tight binding can induce Bak homo-oligomerization. Here we report the ligand-induced Bak conformational cha...

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Detalles Bibliográficos
Autores principales: Pang, Yuan-Ping, Dai, Haiming, Smith, Alyson, Meng, X. Wei, Schneider, Paula A., Kaufmann, Scott H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277102/
https://www.ncbi.nlm.nih.gov/pubmed/22355769
http://dx.doi.org/10.1038/srep00257

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