Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice

BACKGROUND: The 5-lipoxygenase (5LO) enzymatic pathway is widely distributed within the central nervous system. Previous works showed that this protein is up-regulated in Alzheimer's disease (AD), and that its genetic absence results in a reduction of Amyloid beta (Aβ) levels in the Tg2576 mice...

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Detalles Bibliográficos
Autores principales: Chu, Jin, Giannopoulos, Phillip F, Ceballos-Diaz, Carolina, Golde, Todd E, Pratico, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277480/
https://www.ncbi.nlm.nih.gov/pubmed/22222029
http://dx.doi.org/10.1186/1750-1326-7-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277480/
https://www.ncbi.nlm.nih.gov/pubmed/22222029
http://dx.doi.org/10.1186/1750-1326-7-1

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