Cargando…

Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice

BACKGROUND: The 5-lipoxygenase (5LO) enzymatic pathway is widely distributed within the central nervous system. Previous works showed that this protein is up-regulated in Alzheimer's disease (AD), and that its genetic absence results in a reduction of Amyloid beta (Aβ) levels in the Tg2576 mice...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chu, Jin, Giannopoulos, Phillip F, Ceballos-Diaz, Carolina, Golde, Todd E, Pratico, Domenico
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277480/ https://www.ncbi.nlm.nih.gov/pubmed/22222029 http://dx.doi.org/10.1186/1750-1326-7-1

Ejemplares similares

The direct role of 5-lipoxygenase on tau pathology, synaptic integrity and cognition in a mouse model of tauopathy
por: Vagnozzi, Alana N., et al.
Publicado: (2017)

Brain 5‐lipoxygenase over‐expression worsens memory, synaptic integrity, and tau pathology in the P301S mice
por: Vagnozzi, Alana N., et al.
Publicado: (2017)

Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer’s disease mouse model
por: Chu, Jin, et al.
Publicado: (2012)

The 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimer’s disease phenotype
por: Joshi, Yash B., et al.
Publicado: (2015)

Gene Knockout of 5-Lipoxygenase Rescues Synaptic Dysfunction and Improves Memory in the Triple-Transgenic Model of Alzheimer’s Disease
por: Giannopoulos, Phillip F., et al.
Publicado: (2013)

Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer’s phenotype
por: Li, Jian-Guo, et al.
Publicado: (2017)

The 5-Lipoxygenase as a Common Pathway for Pathological Brain and Vascular Aging
por: Chu, Jin, et al.
Publicado: (2009)

Knockout of 5-Lipoxygenase Results in Age-Dependent Anxiety-Like Behavior in Female Mice
por: Joshi, Yash B., et al.
Publicado: (2011)

Involvement of 5-Lipoxygenase in the Corticosteroid-Dependent Amyloid Beta Formation: In Vitro and In Vivo Evidence
por: Puccio, Simone, et al.
Publicado: (2011)

Homocysteine modulates 5‐lipoxygenase expression level via DNA methylation
por: Li, Jian‐Guo, et al.
Publicado: (2016)

Dissecting the Role of 5-Lipoxygenase in the Homocysteine-Induced Alzheimer’s Disease Pathology
por: Di Meco, Antonio, et al.
Publicado: (2018)

Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence
por: Chu, Jin, et al.
Publicado: (2015)

Antileukotriene therapy by reducing tau phosphorylation improves synaptic integrity and cognition of P301S transgenic mice
por: Giannopoulos, Phillip F., et al.
Publicado: (2018)

Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo
por: Chakrabarty, Paramita, et al.
Publicado: (2011)

Adeno-Associated Virus-Mediated Rescue of the Cognitive Defects in a Mouse Model for Angelman Syndrome
por: Daily, Jennifer L., et al.
Publicado: (2011)

Tanshinone IIA Alleviates the AD Phenotypes in APP and PS1 Transgenic Mice
por: Li, Fengling, et al.
Publicado: (2016)

Gene Delivery to Nonhuman Primate Preimplantation Embryos Using Recombinant Adeno‐Associated Virus
por: Wang, Dan, et al.
Publicado: (2019)

Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition
por: Chakrabarty, Paramita, et al.
Publicado: (2012)

Bioactive Peptides and Protein Hydrolysates as Lipoxygenase Inhibitors
por: Wong, Fai-Chu, et al.
Publicado: (2023)

Targeting Adeno-Associated Virus Vectors for Local Delivery to Fractures and Systemic Delivery to the Skeleton
por: Lee, Lucinda R., et al.
Publicado: (2019)

Anti-tau scFvs Targeted to the Cytoplasm or Secretory Pathway Variably Modify Pathology and Neurodegenerative Phenotypes
por: Goodwin, Marshall S., et al.
Publicado: (2021)

γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not
por: Lessard, Christian B., et al.
Publicado: (2020)

Lipoxygenases—Killers against Their Will?
por: Friedmann Angeli, José Pedro, et al.
Publicado: (2018)

Avenanthramides as lipoxygenase inhibitors
por: Landberg, Rikard, et al.
Publicado: (2020)

Perinatal systemic gene delivery using adeno-associated viral vectors
por: Karda, Rajvinder, et al.
Publicado: (2014)

Enhancing gene delivery of adeno-associated viruses by cell-permeable peptides
por: Liu, Yarong, et al.
Publicado: (2014)

Chemical modification of the adeno-associated virus capsid to improve gene delivery
por: Mével, Mathieu, et al.
Publicado: (2019)

Adeno-Viren
por: Falke, Dietrich
Publicado: (2009)

γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP)
por: Lessard, Christian B., et al.
Publicado: (2015)

Elevated levels of brain homocysteine directly modulates the pathological phenotype of a mouse model of tauopathy
por: Di Meco, Antonio, et al.
Publicado: (2018)

Full recovery of the Alzheimer’s disease phenotype by gain of function of Vacuolar Protein Sorting 35
por: Li, Jian-Guo, et al.
Publicado: (2019)

Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids
por: Gheorghe, Karina Roxana, et al.
Publicado: (2009)

Evolution and Expansion of the Prokaryote-Like Lipoxygenase Family in the Brown Alga Saccharina japonica
por: Teng, Linhong, et al.
Publicado: (2017)

Up-regulation of 12(S)-lipoxygenase induces a migratory phenotype in colorectal cancer cells
por: Klampfl, T., et al.
Publicado: (2012)

Inhibition of Soybean 15-Lipoxygenase and Human 5-Lipoxygenase by Extracts of Leaves, Stem Bark, Phenols and Catechols Isolated From Lithraea caustica (Anacardiaceae)
por: Muñoz-Ramírez, Alejandra, et al.
Publicado: (2020)

Intracerebral but Not Peripheral Infection of Live Porphyromonas gingivalis Exacerbates Alzheimer’s Disease Like Amyloid Pathology in APP-TgCRND8 Mice
por: Aravindraja, Chairmandurai, et al.
Publicado: (2022)

Systemic gene delivery to the central nervous system using Adeno-associated virus
por: Bourdenx, Mathieu, et al.
Publicado: (2014)

Creating an arsenal of Adeno-associated virus (AAV) gene delivery stealth vehicles
por: Smith, J. Kennon, et al.
Publicado: (2018)

Adeno-Associated Viral Vectors as a Tool for Large Gene Delivery to the Retina
por: Trapani, Ivana
Publicado: (2019)

Seek and destroy: targeted adeno-associated viruses for gene delivery to hepatocellular carcinoma
por: Dhungel, Bijay, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_9uvon5u1pe1l33agedhl902s0f