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Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay

BACKGROUND: Histone deacetylase inhibitors (HDACi) display potent therapeutic efficacy in animal models of arthritis and suppress inflammatory cytokine production in rheumatoid arthritis (RA) synovial macrophages and tissue. OBJECTIVES: To determine the molecular mechanisms contributing to the suppr...

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Detalles Bibliográficos
Autores principales:	Grabiec, Aleksander M, Korchynskyi, Olexandr, Tak, Paul P, Reedquist, Kris A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Group 2011
Materias:	Basic and Translational Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277722/ https://www.ncbi.nlm.nih.gov/pubmed/21953341 http://dx.doi.org/10.1136/ard.2011.154211

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