Knocking Out Angiotensin II in the Heart

Despite ongoing medical advances, cardiovascular disease continues to be a leading health concern. The renin-angiotensin system (RAS) plays an important role in regulating cardiovascular function, and is, therefore, the subject of extensive study. Several drugs currently used to treat hypertension a...

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Detalles Bibliográficos
Autores principales: Zablocki, Daniela, Sadoshima, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Current Science Inc. 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278322/
https://www.ncbi.nlm.nih.gov/pubmed/21234717
http://dx.doi.org/10.1007/s11906-011-0180-4
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author Zablocki, Daniela
Sadoshima, Junichi
author_facet Zablocki, Daniela
Sadoshima, Junichi
author_sort Zablocki, Daniela
collection PubMed
description Despite ongoing medical advances, cardiovascular disease continues to be a leading health concern. The renin-angiotensin system (RAS) plays an important role in regulating cardiovascular function, and is, therefore, the subject of extensive study. Several drugs currently used to treat hypertension and heart failure are designed to target angiotensin II synthesis and function, but thus far, none have been able to completely block the effects of RAS signaling. This review discusses current and emerging approaches towards inhibiting cardiac RAS function in order to further improve cardiovascular disease outcomes.
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spelling pubmed-32783222012-04-01 Knocking Out Angiotensin II in the Heart Zablocki, Daniela Sadoshima, Junichi Curr Hypertens Rep Article Despite ongoing medical advances, cardiovascular disease continues to be a leading health concern. The renin-angiotensin system (RAS) plays an important role in regulating cardiovascular function, and is, therefore, the subject of extensive study. Several drugs currently used to treat hypertension and heart failure are designed to target angiotensin II synthesis and function, but thus far, none have been able to completely block the effects of RAS signaling. This review discusses current and emerging approaches towards inhibiting cardiac RAS function in order to further improve cardiovascular disease outcomes. Current Science Inc. 2011-01-14 2011 /pmc/articles/PMC3278322/ /pubmed/21234717 http://dx.doi.org/10.1007/s11906-011-0180-4 Text en © Springer Science+Business Media, LLC 2011 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Zablocki, Daniela
Sadoshima, Junichi
Knocking Out Angiotensin II in the Heart
title Knocking Out Angiotensin II in the Heart
title_full Knocking Out Angiotensin II in the Heart
title_fullStr Knocking Out Angiotensin II in the Heart
title_full_unstemmed Knocking Out Angiotensin II in the Heart
title_short Knocking Out Angiotensin II in the Heart
title_sort knocking out angiotensin ii in the heart
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278322/
https://www.ncbi.nlm.nih.gov/pubmed/21234717
http://dx.doi.org/10.1007/s11906-011-0180-4
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