Neuromelanin, neurotransmitter status and brainstem location determine the differential vulnerability of catecholaminergic neurons to mitochondrial DNA deletions

BACKGROUND: Deletions of the mitochondrial DNA (mtDNA) accumulate to high levels in dopaminergic neurons of the substantia nigra pars compacta (SNc) in normal aging and in patients with Parkinson's disease (PD). Human nigral neurons characteristically contain the pigment neuromelanin (NM), whic...

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Detalles Bibliográficos
Autores principales: Elstner, Matthias, Müller, Sarina K, Leidolt, Lars, Laub, Christoph, Krieg, Lena, Schlaudraff, Falk, Liss, Birgit, Morris, Chris, Turnbull, Douglass M, Masliah, Eliezer, Prokisch, Holger, Klopstock, Thomas, Bender, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278372/
https://www.ncbi.nlm.nih.gov/pubmed/22188897
http://dx.doi.org/10.1186/1756-6606-4-43

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