TBC1D3, a Hominoid-Specific Gene, Delays IRS-1 Degradation and Promotes Insulin Signaling by Modulating p70 S6 Kinase Activity

Insulin/IGF-1 signaling plays a pivotal role in the regulation of cellular homeostasis through its control of glucose metabolism as well as due to its effects on cell proliferation. Aberrant regulation of insulin signaling has been repeatedly implicated in uncontrolled cell growth and malignant tran...

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Detalles Bibliográficos
Autores principales: Wainszelbaum, Marisa J., Liu, Jialu, Kong, Chen, Srikanth, Priya, Samovski, Dmitri, Su, Xiong, Stahl, Philip D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278430/
https://www.ncbi.nlm.nih.gov/pubmed/22348058
http://dx.doi.org/10.1371/journal.pone.0031225

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