Cargando…

Multidisciplinary treatment and long-term outcomes in six patients with leiomyosarcoma of the inferior vena cava

PURPOSE: Leiomyosarcoma (LMS) of the inferior vena cava (IVC) is a rare primary soft tissue sarcoma. Few reports have detailed the tumor features, treatment strategies, and long-term outcomes in IVC LMS patients. The present report describes the treatment and long-term outcomes of six patients with...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Jihoon T, Kwon, Teawon, Cho, Yongpil, Shin, Sung, Lee, Sunggyu, Moon, Deokbog
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Surgical Society 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278631/
https://www.ncbi.nlm.nih.gov/pubmed/22347712
http://dx.doi.org/10.4174/jkss.2012.82.2.101
_version_ 1782223596401197056
author Kim, Jihoon T
Kwon, Teawon
Cho, Yongpil
Shin, Sung
Lee, Sunggyu
Moon, Deokbog
author_facet Kim, Jihoon T
Kwon, Teawon
Cho, Yongpil
Shin, Sung
Lee, Sunggyu
Moon, Deokbog
author_sort Kim, Jihoon T
collection PubMed
description PURPOSE: Leiomyosarcoma (LMS) of the inferior vena cava (IVC) is a rare primary soft tissue sarcoma. Few reports have detailed the tumor features, treatment strategies, and long-term outcomes in IVC LMS patients. The present report describes the treatment and long-term outcomes of six patients with IVC LMS. METHODS: We reviewed six consecutive cases of IVC LMS treated at the University of Ulsan College of Medicine, Asan Medical Center from August 1998 to June 2010. RESULTS: The patients comprised five females and one male, and had a median age of 44 years (range, 25 to 64 years). All tumors were suprarenal. The tumors were located between the hepatic and renal veins (i.e., middle segment; n = 5 [83%]), or above the hepatic veins (i.e., upper segment; n = 1 [17%]). Prosthetic IVC replacement using polytetrafluoroethylene grafts was performed in five patients, and the remaining patient underwent only tumor resection and IVC ligation. There were no intraoperative or postoperative deaths. The mean tumor size was 9.3 cm (range, 5 to 20 cm), and five of the six tumors were high grade. The mean follow-up period was 80 months (range, 6 to 118 months). The median survival period was 94 months. Recurrence occurred in all patients. Distant recurrence resulted in three patients undergoing lung resection and three patients undergoing thigh muscle resection. CONCLUSION: IVC LMS is a rare but serious disease. Although surgical resection combined with chemoradiotherapy was not completely curative, it resulted in long-term patient survival, even in patients with advanced tumors.
format Online
Article
Text
id pubmed-3278631
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher The Korean Surgical Society
record_format MEDLINE/PubMed
spelling pubmed-32786312012-02-16 Multidisciplinary treatment and long-term outcomes in six patients with leiomyosarcoma of the inferior vena cava Kim, Jihoon T Kwon, Teawon Cho, Yongpil Shin, Sung Lee, Sunggyu Moon, Deokbog J Korean Surg Soc Original Article PURPOSE: Leiomyosarcoma (LMS) of the inferior vena cava (IVC) is a rare primary soft tissue sarcoma. Few reports have detailed the tumor features, treatment strategies, and long-term outcomes in IVC LMS patients. The present report describes the treatment and long-term outcomes of six patients with IVC LMS. METHODS: We reviewed six consecutive cases of IVC LMS treated at the University of Ulsan College of Medicine, Asan Medical Center from August 1998 to June 2010. RESULTS: The patients comprised five females and one male, and had a median age of 44 years (range, 25 to 64 years). All tumors were suprarenal. The tumors were located between the hepatic and renal veins (i.e., middle segment; n = 5 [83%]), or above the hepatic veins (i.e., upper segment; n = 1 [17%]). Prosthetic IVC replacement using polytetrafluoroethylene grafts was performed in five patients, and the remaining patient underwent only tumor resection and IVC ligation. There were no intraoperative or postoperative deaths. The mean tumor size was 9.3 cm (range, 5 to 20 cm), and five of the six tumors were high grade. The mean follow-up period was 80 months (range, 6 to 118 months). The median survival period was 94 months. Recurrence occurred in all patients. Distant recurrence resulted in three patients undergoing lung resection and three patients undergoing thigh muscle resection. CONCLUSION: IVC LMS is a rare but serious disease. Although surgical resection combined with chemoradiotherapy was not completely curative, it resulted in long-term patient survival, even in patients with advanced tumors. The Korean Surgical Society 2012-02 2012-01-27 /pmc/articles/PMC3278631/ /pubmed/22347712 http://dx.doi.org/10.4174/jkss.2012.82.2.101 Text en Copyright © 2012, the Korean Surgical Society http://creativecommons.org/licenses/by-nc/3.0 Journal of the Korean Surgical Society is an Open Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Jihoon T
Kwon, Teawon
Cho, Yongpil
Shin, Sung
Lee, Sunggyu
Moon, Deokbog
Multidisciplinary treatment and long-term outcomes in six patients with leiomyosarcoma of the inferior vena cava
title Multidisciplinary treatment and long-term outcomes in six patients with leiomyosarcoma of the inferior vena cava
title_full Multidisciplinary treatment and long-term outcomes in six patients with leiomyosarcoma of the inferior vena cava
title_fullStr Multidisciplinary treatment and long-term outcomes in six patients with leiomyosarcoma of the inferior vena cava
title_full_unstemmed Multidisciplinary treatment and long-term outcomes in six patients with leiomyosarcoma of the inferior vena cava
title_short Multidisciplinary treatment and long-term outcomes in six patients with leiomyosarcoma of the inferior vena cava
title_sort multidisciplinary treatment and long-term outcomes in six patients with leiomyosarcoma of the inferior vena cava
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278631/
https://www.ncbi.nlm.nih.gov/pubmed/22347712
http://dx.doi.org/10.4174/jkss.2012.82.2.101
work_keys_str_mv AT kimjihoont multidisciplinarytreatmentandlongtermoutcomesinsixpatientswithleiomyosarcomaoftheinferiorvenacava
AT kwonteawon multidisciplinarytreatmentandlongtermoutcomesinsixpatientswithleiomyosarcomaoftheinferiorvenacava
AT choyongpil multidisciplinarytreatmentandlongtermoutcomesinsixpatientswithleiomyosarcomaoftheinferiorvenacava
AT shinsung multidisciplinarytreatmentandlongtermoutcomesinsixpatientswithleiomyosarcomaoftheinferiorvenacava
AT leesunggyu multidisciplinarytreatmentandlongtermoutcomesinsixpatientswithleiomyosarcomaoftheinferiorvenacava
AT moondeokbog multidisciplinarytreatmentandlongtermoutcomesinsixpatientswithleiomyosarcomaoftheinferiorvenacava