Clinicopathologic change of gastrointestinal stromal tumor after neoadjuvant imatinib followed by surgical resection

A 53-year-old woman was diagnosed with gastrointestinal stromal tumor (GIST) of the stomach. Computed tomography (CT) revealed a huge mass (12 cm in diameter), likely to invade pancreas and spleen. In the operation field, the tumor was in an unresectable state. The patient was then started on imatin...

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Detalles Bibliográficos
Autores principales: Kang, Gil Ho, Son, Myoung Won, Han, Sun Wook, Bae, Sang Ho, Kim, Sung Yong, Kim, Yong Jin, Chung, Gui Ae, Cho, Gyu Seok, Lee, Moon Soo, Park, Nae Kyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Surgical Society 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278634/
https://www.ncbi.nlm.nih.gov/pubmed/22347715
http://dx.doi.org/10.4174/jkss.2012.82.2.120
Descripción
Sumario:A 53-year-old woman was diagnosed with gastrointestinal stromal tumor (GIST) of the stomach. Computed tomography (CT) revealed a huge mass (12 cm in diameter), likely to invade pancreas and spleen. In the operation field, the tumor was in an unresectable state. The patient was then started on imatinib therapy for 4 months. On follow-up imaging studies, the tumor almost disappeared. We performed total gastrectomy and splenectomy upon which two small-sized residual tumors were found on microscopy. In this paper, we describe a case of clinicopathologic change in unresectable GIST after neoadjuvant imatinib mesylate.

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