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Extraosseous (extramedullary) plasmacytomas: a clinicopathologic and immunophenotypic study of 32 Chinese cases

BACKGROUND: Extraosseous plasmacytoma, so called extramedullary plasmacytoma (EMP) is relatively rare in China. The aim was investigate the clinicopathologic features of EMP and the role of Immunophenotype and genotype detection in diagnosis of EMP. METHODS: Thirty-two cases of EMP were investigated...

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Autores principales: Zuo, Zhuo, Tang, Yuan, Bi, Cheng-Feng, Zhang, Wen-Yan, Zhao, Sha, Wang, Xiao-Qing, Yang, Qun-Pei, Zou, Li-Qun, Liu, Wei-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278682/
https://www.ncbi.nlm.nih.gov/pubmed/22182738
http://dx.doi.org/10.1186/1746-1596-6-123
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author Zuo, Zhuo
Tang, Yuan
Bi, Cheng-Feng
Zhang, Wen-Yan
Zhao, Sha
Wang, Xiao-Qing
Yang, Qun-Pei
Zou, Li-Qun
Liu, Wei-Ping
author_facet Zuo, Zhuo
Tang, Yuan
Bi, Cheng-Feng
Zhang, Wen-Yan
Zhao, Sha
Wang, Xiao-Qing
Yang, Qun-Pei
Zou, Li-Qun
Liu, Wei-Ping
author_sort Zuo, Zhuo
collection PubMed
description BACKGROUND: Extraosseous plasmacytoma, so called extramedullary plasmacytoma (EMP) is relatively rare in China. The aim was investigate the clinicopathologic features of EMP and the role of Immunophenotype and genotype detection in diagnosis of EMP. METHODS: Thirty-two cases of EMP were investigated retrospectively by histopathology, immunophenotype, genotype and survival analysis. RESULTS: Clinically, the mean age of the patients was 53.4. Most of the patients received no treatment after the diagnosis was established, and the prognosis was relatively poor. Histologically, in 40% of the cases, the neoplastic cells were grade II or III. The neoplastic cells expressed one or more PC associated antigens. The immunophenotype of EMP and inflammation of sinonasal regions with numerous PC infiltrations were compared and showed some difference in expression of CD45, CD27, CD44v6 and Bcl-2 as well. Ig light chain restriction was detected in 87.5% of the cases. CONCLUSIONS: we described 32 Chinese cases of EMP, compare with that reported in the literature, some differences are presented, including higher percentage of grade II and III cases, clinically inconsistent treatment and management as well as poor outcome of the disease.
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spelling pubmed-32786822012-02-14 Extraosseous (extramedullary) plasmacytomas: a clinicopathologic and immunophenotypic study of 32 Chinese cases Zuo, Zhuo Tang, Yuan Bi, Cheng-Feng Zhang, Wen-Yan Zhao, Sha Wang, Xiao-Qing Yang, Qun-Pei Zou, Li-Qun Liu, Wei-Ping Diagn Pathol Research BACKGROUND: Extraosseous plasmacytoma, so called extramedullary plasmacytoma (EMP) is relatively rare in China. The aim was investigate the clinicopathologic features of EMP and the role of Immunophenotype and genotype detection in diagnosis of EMP. METHODS: Thirty-two cases of EMP were investigated retrospectively by histopathology, immunophenotype, genotype and survival analysis. RESULTS: Clinically, the mean age of the patients was 53.4. Most of the patients received no treatment after the diagnosis was established, and the prognosis was relatively poor. Histologically, in 40% of the cases, the neoplastic cells were grade II or III. The neoplastic cells expressed one or more PC associated antigens. The immunophenotype of EMP and inflammation of sinonasal regions with numerous PC infiltrations were compared and showed some difference in expression of CD45, CD27, CD44v6 and Bcl-2 as well. Ig light chain restriction was detected in 87.5% of the cases. CONCLUSIONS: we described 32 Chinese cases of EMP, compare with that reported in the literature, some differences are presented, including higher percentage of grade II and III cases, clinically inconsistent treatment and management as well as poor outcome of the disease. BioMed Central 2011-12-19 /pmc/articles/PMC3278682/ /pubmed/22182738 http://dx.doi.org/10.1186/1746-1596-6-123 Text en Copyright ©2011 Zuo et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Zuo, Zhuo
Tang, Yuan
Bi, Cheng-Feng
Zhang, Wen-Yan
Zhao, Sha
Wang, Xiao-Qing
Yang, Qun-Pei
Zou, Li-Qun
Liu, Wei-Ping
Extraosseous (extramedullary) plasmacytomas: a clinicopathologic and immunophenotypic study of 32 Chinese cases
title Extraosseous (extramedullary) plasmacytomas: a clinicopathologic and immunophenotypic study of 32 Chinese cases
title_full Extraosseous (extramedullary) plasmacytomas: a clinicopathologic and immunophenotypic study of 32 Chinese cases
title_fullStr Extraosseous (extramedullary) plasmacytomas: a clinicopathologic and immunophenotypic study of 32 Chinese cases
title_full_unstemmed Extraosseous (extramedullary) plasmacytomas: a clinicopathologic and immunophenotypic study of 32 Chinese cases
title_short Extraosseous (extramedullary) plasmacytomas: a clinicopathologic and immunophenotypic study of 32 Chinese cases
title_sort extraosseous (extramedullary) plasmacytomas: a clinicopathologic and immunophenotypic study of 32 chinese cases
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278682/
https://www.ncbi.nlm.nih.gov/pubmed/22182738
http://dx.doi.org/10.1186/1746-1596-6-123
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