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Non-nucleosidic inhibition of Herpes simplex virus DNA polymerase: mechanistic insights into the anti-herpetic mode of action of herbal drug withaferin A

BACKGROUND: Herpes Simplex Virus 1 and 2 causes several infections in humans including cold sores and encephalitis. Previous antiviral studies on herpes viruses have focussed on developing nucleoside analogues that can inhibit viral polymerase and terminate the replicating viral DNA. However, these...

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Detalles Bibliográficos
Autores principales:	Grover, Abhinav, Agrawal, Vibhuti, Shandilya, Ashutosh, Bisaria, Virendra S, Sundar, Durai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Proceedings
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278839/ https://www.ncbi.nlm.nih.gov/pubmed/22373101 http://dx.doi.org/10.1186/1471-2105-12-S13-S22

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