Effect of the rd1 mutation on motor performance in R6/2 and wild type mice

Homozygosis for the rd1 mutation in the Pbe6b gene results in the loss of the rod beta-subunit of the cyclic GMP phosphodiesterase and, eventually, of all rod and cone photoreceptors. The R6/2 mouse line is a widely used model of Huntington’s disease (HD). The original line was made available on a m...

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Detalles Bibliográficos
Autores principales: Menalled, Liliana, El-Khodor, Bassem F., Hornberger, Monica, Park, Larry, Howland, David, Brunner, Dani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Huntington Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278853/
https://www.ncbi.nlm.nih.gov/pubmed/22367489
http://dx.doi.org/10.1371/currents.RRN1303

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