Cargando…
Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73
N-[(4-trifluoromethyl)benzyl]4-methoxybutyramide (GET73) is a newly synthesized compound structurally related to the clinically used, alcohol-substituting agent, gamma-hydroxybutyric acid (GHB). The present study was designed to assess whether GET73 may share with GHB the capacity to reduce alcohol...
Autores principales: | Loche, Antonella, Simonetti, Francesco, Lobina, Carla, Carai, Mauro A. M., Colombo, Giancarlo, Castelli, M. Paola, Barone, Domenico, Cacciaglia, Roberto |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Research Foundation
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278888/ https://www.ncbi.nlm.nih.gov/pubmed/22347868 http://dx.doi.org/10.3389/fpsyt.2012.00008 |
Ejemplares similares
-
In Vitro Functional Characterization of GET73 as Possible Negative Allosteric Modulator of Metabotropic Glutamate Receptor 5
por: Beggiato, Sarah, et al.
Publicado: (2018) -
Activation of the GABA(B) Receptor Prevents Nicotine-Induced Locomotor Stimulation in Mice
por: Lobina, Carla, et al.
Publicado: (2011) -
Suppression by γ-Hydroxybutyric Acid of “Alcohol Deprivation Effect” in Rats: Preclinical Evidence of its anti-Relapse Properties
por: Colombo, Giancarlo, et al.
Publicado: (2012) -
Reduction by the Positive Allosteric Modulator of the GABA(B) Receptor, GS39783, of Alcohol Self-Administration in Sardinian Alcohol-Preferring Rats Exposed to the “Sipper” Procedure
por: Maccioni, Paola, et al.
Publicado: (2010) -
Dataset for Phase I randomized clinical trial for safety and tolerability of GET 73 in single and repeated ascending doses including preliminary pharmacokinetic parameters
por: Haass-Koffler, Carolina L., et al.
Publicado: (2017)