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Activating Transcription Factor 3 and the Nervous System

Activating transcription factor 3 (ATF3) belongs to the ATF/cyclic AMP responsive element binding family of transcription factors and is often described as an adaptive response gene whose activity is usually regulated by stressful stimuli. Although expressed in a number of splice variants and genera...

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Autores principales: Hunt, David, Raivich, Gennadij, Anderson, Patrick Norval
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278981/
https://www.ncbi.nlm.nih.gov/pubmed/22347845
http://dx.doi.org/10.3389/fnmol.2012.00007
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author Hunt, David
Raivich, Gennadij
Anderson, Patrick Norval
author_facet Hunt, David
Raivich, Gennadij
Anderson, Patrick Norval
author_sort Hunt, David
collection PubMed
description Activating transcription factor 3 (ATF3) belongs to the ATF/cyclic AMP responsive element binding family of transcription factors and is often described as an adaptive response gene whose activity is usually regulated by stressful stimuli. Although expressed in a number of splice variants and generally recognized as a transcriptional repressor, ATF3 has the ability to interact with a number of other transcription factors including c-Jun to form complexes which not only repress, but can also activate various genes. ATF3 expression is modulated mainly at the transcriptional level and has markedly different effects in different types of cell. The levels of ATF3 mRNA and protein are normally very low in neurons and glia but their expression is rapidly upregulated in response to injury. ATF3 expression in neurons is closely linked to their survival and the regeneration of their axons following axotomy, and that in peripheral nerves correlates with the generation of a Schwann cell phenotype that is conducive to axonal regeneration. ATF3 is also induced by Toll-like receptor (TLR) ligands but acts as a negative regulator of TLR signaling, suppressing the innate immune response which is involved in immuno-surveillance and can enhance or reduce the survival of injured neurons and promote the regeneration of their axons.
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spelling pubmed-32789812012-02-17 Activating Transcription Factor 3 and the Nervous System Hunt, David Raivich, Gennadij Anderson, Patrick Norval Front Mol Neurosci Neuroscience Activating transcription factor 3 (ATF3) belongs to the ATF/cyclic AMP responsive element binding family of transcription factors and is often described as an adaptive response gene whose activity is usually regulated by stressful stimuli. Although expressed in a number of splice variants and generally recognized as a transcriptional repressor, ATF3 has the ability to interact with a number of other transcription factors including c-Jun to form complexes which not only repress, but can also activate various genes. ATF3 expression is modulated mainly at the transcriptional level and has markedly different effects in different types of cell. The levels of ATF3 mRNA and protein are normally very low in neurons and glia but their expression is rapidly upregulated in response to injury. ATF3 expression in neurons is closely linked to their survival and the regeneration of their axons following axotomy, and that in peripheral nerves correlates with the generation of a Schwann cell phenotype that is conducive to axonal regeneration. ATF3 is also induced by Toll-like receptor (TLR) ligands but acts as a negative regulator of TLR signaling, suppressing the innate immune response which is involved in immuno-surveillance and can enhance or reduce the survival of injured neurons and promote the regeneration of their axons. Frontiers Research Foundation 2012-02-14 /pmc/articles/PMC3278981/ /pubmed/22347845 http://dx.doi.org/10.3389/fnmol.2012.00007 Text en Copyright © 2012 Hunt, Raivich and Anderson. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Neuroscience
Hunt, David
Raivich, Gennadij
Anderson, Patrick Norval
Activating Transcription Factor 3 and the Nervous System
title Activating Transcription Factor 3 and the Nervous System
title_full Activating Transcription Factor 3 and the Nervous System
title_fullStr Activating Transcription Factor 3 and the Nervous System
title_full_unstemmed Activating Transcription Factor 3 and the Nervous System
title_short Activating Transcription Factor 3 and the Nervous System
title_sort activating transcription factor 3 and the nervous system
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278981/
https://www.ncbi.nlm.nih.gov/pubmed/22347845
http://dx.doi.org/10.3389/fnmol.2012.00007
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