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Exploitation of Lipid Components by Viral and Host Proteins for Hepatitis C Virus Infection

Hepatitis C virus (HCV), which is a major causative agent of blood-borne hepatitis, has chronically infected about 170 million individuals worldwide and leads to chronic infection, resulting in development of steatosis, cirrhosis, and eventually hepatocellular carcinoma. Hepatocellular carcinoma ass...

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Autores principales: Moriishi, Kohji, Matsuura, Yashiharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278987/
https://www.ncbi.nlm.nih.gov/pubmed/22347882
http://dx.doi.org/10.3389/fmicb.2012.00054
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author Moriishi, Kohji
Matsuura, Yashiharu
author_facet Moriishi, Kohji
Matsuura, Yashiharu
author_sort Moriishi, Kohji
collection PubMed
description Hepatitis C virus (HCV), which is a major causative agent of blood-borne hepatitis, has chronically infected about 170 million individuals worldwide and leads to chronic infection, resulting in development of steatosis, cirrhosis, and eventually hepatocellular carcinoma. Hepatocellular carcinoma associated with HCV infection is not only caused by chronic inflammation, but also by the biological activity of HCV proteins. HCV core protein is known as a main component of the viral nucleocapsid. It cooperates with host factors and possesses biological activity causing lipid alteration, oxidative stress, and progression of cell growth, while other viral proteins also interact with host proteins including molecular chaperones, membrane-anchoring proteins, and enzymes associated with lipid metabolism to maintain the efficiency of viral replication and production. HCV core protein is localized on the surface of lipid droplets in infected cells. However, the role of lipid droplets in HCV infection has not yet been elucidated. Several groups recently reported that other viral proteins also support viral infection by regulation of lipid droplets and core localization in infected cells. Furthermore, lipid components are required for modification of host factors and the intracellular membrane to maintain or up-regulate viral replication. In this review, we summarize the current status of knowledge regarding the exploitation of lipid components by viral and host proteins in HCV infection.
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spelling pubmed-32789872012-02-17 Exploitation of Lipid Components by Viral and Host Proteins for Hepatitis C Virus Infection Moriishi, Kohji Matsuura, Yashiharu Front Microbiol Microbiology Hepatitis C virus (HCV), which is a major causative agent of blood-borne hepatitis, has chronically infected about 170 million individuals worldwide and leads to chronic infection, resulting in development of steatosis, cirrhosis, and eventually hepatocellular carcinoma. Hepatocellular carcinoma associated with HCV infection is not only caused by chronic inflammation, but also by the biological activity of HCV proteins. HCV core protein is known as a main component of the viral nucleocapsid. It cooperates with host factors and possesses biological activity causing lipid alteration, oxidative stress, and progression of cell growth, while other viral proteins also interact with host proteins including molecular chaperones, membrane-anchoring proteins, and enzymes associated with lipid metabolism to maintain the efficiency of viral replication and production. HCV core protein is localized on the surface of lipid droplets in infected cells. However, the role of lipid droplets in HCV infection has not yet been elucidated. Several groups recently reported that other viral proteins also support viral infection by regulation of lipid droplets and core localization in infected cells. Furthermore, lipid components are required for modification of host factors and the intracellular membrane to maintain or up-regulate viral replication. In this review, we summarize the current status of knowledge regarding the exploitation of lipid components by viral and host proteins in HCV infection. Frontiers Research Foundation 2012-02-14 /pmc/articles/PMC3278987/ /pubmed/22347882 http://dx.doi.org/10.3389/fmicb.2012.00054 Text en Copyright © 2012 Moriishi and Matsuura. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Microbiology
Moriishi, Kohji
Matsuura, Yashiharu
Exploitation of Lipid Components by Viral and Host Proteins for Hepatitis C Virus Infection
title Exploitation of Lipid Components by Viral and Host Proteins for Hepatitis C Virus Infection
title_full Exploitation of Lipid Components by Viral and Host Proteins for Hepatitis C Virus Infection
title_fullStr Exploitation of Lipid Components by Viral and Host Proteins for Hepatitis C Virus Infection
title_full_unstemmed Exploitation of Lipid Components by Viral and Host Proteins for Hepatitis C Virus Infection
title_short Exploitation of Lipid Components by Viral and Host Proteins for Hepatitis C Virus Infection
title_sort exploitation of lipid components by viral and host proteins for hepatitis c virus infection
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278987/
https://www.ncbi.nlm.nih.gov/pubmed/22347882
http://dx.doi.org/10.3389/fmicb.2012.00054
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