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Occupational exposure to chemicals and fetal growth: the Generation R Study

BACKGROUND: Developmental diseases, such as birth defects, growth restriction and preterm delivery, account for >25% of infant mortality and morbidity. Several studies have shown that exposure to chemicals during pregnancy is associated with adverse birth outcomes. The aim of this study was to id...

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Autores principales: Snijder, Claudia A., Roeleveld, Nel, te Velde, Egbert, Steegers, Eric A.P., Raat, Hein, Hofman, Albert, Jaddoe, Vincent W.V., Burdorf, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279127/
https://www.ncbi.nlm.nih.gov/pubmed/22215632
http://dx.doi.org/10.1093/humrep/der437
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author Snijder, Claudia A.
Roeleveld, Nel
te Velde, Egbert
Steegers, Eric A.P.
Raat, Hein
Hofman, Albert
Jaddoe, Vincent W.V.
Burdorf, Alex
author_facet Snijder, Claudia A.
Roeleveld, Nel
te Velde, Egbert
Steegers, Eric A.P.
Raat, Hein
Hofman, Albert
Jaddoe, Vincent W.V.
Burdorf, Alex
author_sort Snijder, Claudia A.
collection PubMed
description BACKGROUND: Developmental diseases, such as birth defects, growth restriction and preterm delivery, account for >25% of infant mortality and morbidity. Several studies have shown that exposure to chemicals during pregnancy is associated with adverse birth outcomes. The aim of this study was to identify whether occupational exposure to various chemicals might adversely influence intrauterine growth patterns and placental weight. METHODS: Associations between maternal occupational exposure to various chemicals and fetal growth were studied in 4680 pregnant women participating in a population-based prospective cohort study from early pregnancy onwards in the Netherlands (2002–2006), the Generation R Study. Mothers who filled out a questionnaire during mid-pregnancy (response: 77% of enrolment) were included if they conducted paid employment during pregnancy and had a spontaneously conceived singleton live born pregnancy (n = 4680). A job exposure matrix was used, linking job titles to expert judgement on exposure to chemicals in the workplace. Fetal growth characteristics were repeatedly measured by ultrasound and were used in combination with measurements at birth. Placental weight was obtained from medical records and hospital registries. Linear regression models for repeated measurements were used to study the associations between maternal occupational exposure to chemicals and intrauterine growth. RESULTS: We observed that maternal occupational exposure to polycyclic aromatic hydrocarbons, phthalates, alkylphenolic compounds and pesticides adversely influenced several domains of fetal growth (fetal weight, fetal head circumference and fetal length). We found a significant association between pesticide and phthalate exposure with a decreased placental weight. CONCLUSIONS: Our results suggest that maternal occupational exposure to several chemicals is associated with impaired fetal growth during pregnancy and a decreased placental weight. Further studies are needed to confirm these findings and to assess post-natal consequences.
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spelling pubmed-32791272012-02-15 Occupational exposure to chemicals and fetal growth: the Generation R Study Snijder, Claudia A. Roeleveld, Nel te Velde, Egbert Steegers, Eric A.P. Raat, Hein Hofman, Albert Jaddoe, Vincent W.V. Burdorf, Alex Hum Reprod Original Articles BACKGROUND: Developmental diseases, such as birth defects, growth restriction and preterm delivery, account for >25% of infant mortality and morbidity. Several studies have shown that exposure to chemicals during pregnancy is associated with adverse birth outcomes. The aim of this study was to identify whether occupational exposure to various chemicals might adversely influence intrauterine growth patterns and placental weight. METHODS: Associations between maternal occupational exposure to various chemicals and fetal growth were studied in 4680 pregnant women participating in a population-based prospective cohort study from early pregnancy onwards in the Netherlands (2002–2006), the Generation R Study. Mothers who filled out a questionnaire during mid-pregnancy (response: 77% of enrolment) were included if they conducted paid employment during pregnancy and had a spontaneously conceived singleton live born pregnancy (n = 4680). A job exposure matrix was used, linking job titles to expert judgement on exposure to chemicals in the workplace. Fetal growth characteristics were repeatedly measured by ultrasound and were used in combination with measurements at birth. Placental weight was obtained from medical records and hospital registries. Linear regression models for repeated measurements were used to study the associations between maternal occupational exposure to chemicals and intrauterine growth. RESULTS: We observed that maternal occupational exposure to polycyclic aromatic hydrocarbons, phthalates, alkylphenolic compounds and pesticides adversely influenced several domains of fetal growth (fetal weight, fetal head circumference and fetal length). We found a significant association between pesticide and phthalate exposure with a decreased placental weight. CONCLUSIONS: Our results suggest that maternal occupational exposure to several chemicals is associated with impaired fetal growth during pregnancy and a decreased placental weight. Further studies are needed to confirm these findings and to assess post-natal consequences. Oxford University Press 2012-03 2012-01-02 /pmc/articles/PMC3279127/ /pubmed/22215632 http://dx.doi.org/10.1093/humrep/der437 Text en © The Author 2012. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. http://creativecommons.org/licenses/by-nc/2.5/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Snijder, Claudia A.
Roeleveld, Nel
te Velde, Egbert
Steegers, Eric A.P.
Raat, Hein
Hofman, Albert
Jaddoe, Vincent W.V.
Burdorf, Alex
Occupational exposure to chemicals and fetal growth: the Generation R Study
title Occupational exposure to chemicals and fetal growth: the Generation R Study
title_full Occupational exposure to chemicals and fetal growth: the Generation R Study
title_fullStr Occupational exposure to chemicals and fetal growth: the Generation R Study
title_full_unstemmed Occupational exposure to chemicals and fetal growth: the Generation R Study
title_short Occupational exposure to chemicals and fetal growth: the Generation R Study
title_sort occupational exposure to chemicals and fetal growth: the generation r study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279127/
https://www.ncbi.nlm.nih.gov/pubmed/22215632
http://dx.doi.org/10.1093/humrep/der437
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