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Cryopreserved mesenchymal stromal cells display impaired immunosuppressive properties as a result of heat-shock response and impaired interferon-γ licensing

Human mesenchymal stromal cells (MSC) can suppress T-cell activation in vitro in an indoleamine 2,3-dioxygenase (IDO)-dependent manner. However, their clinical effects on immune ailments have been inconsistent, with a recent phase III study showing no benefit in acute graft-versus-host disease (GvHD...

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Detalles Bibliográficos
Autores principales:	François, Moïra, Copland, Ian B, Yuan, Shala, Romieu-Mourez, Raphaëlle, Waller, Edmund K, Galipeau, Jacques
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Informa Healthcare 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279133/ https://www.ncbi.nlm.nih.gov/pubmed/22029655 http://dx.doi.org/10.3109/14653249.2011.623691

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