Cargando…

SHARPIN Is Essential for Cytokine Production, NF-κB Signaling, and Induction of Th1 Differentiation by Dendritic Cells

Spontaneous mutations of the Sharpin (SHANK-associated RH domain-interacting protein, other aliases: Rbckl1, Sipl1) gene in mice result in systemic inflammation that is characterized by chronic proliferative dermatitis and dysregulated secretion of T helper1 (Th1) and Th2 cytokines. The cellular and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Zhe, Sokolovska, Anna, Seymour, Rosemarie, Sundberg, John P., HogenEsch, Harm
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279418/ https://www.ncbi.nlm.nih.gov/pubmed/22348129 http://dx.doi.org/10.1371/journal.pone.0031809

Ejemplares similares

Loss of Function of the Mouse Sharpin Gene Results in Peyer’s Patch Regression
por: Seymour, Rosemarie, et al.
Publicado: (2013)

SHARPIN is a key regulator of immune and inflammatory responses
por: Wang, Zhe, et al.
Publicado: (2012)

Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice
por: Sundberg, John P., et al.
Publicado: (2020)

Chronic Proliferative Dermatitis in Sharpin Null Mice: Development of an Autoinflammatory Disease in the Absence of B and T Lymphocytes and IL4/IL13 Signaling
por: Potter, Christopher S., et al.
Publicado: (2014)

Mechanism of Immunopotentiation and Safety of Aluminum Adjuvants
por: HogenEsch, Harm
Publicado: (2013)

Serine 165 phosphorylation of SHARPIN regulates the activation of NF-κB
por: Thys, An, et al.
Publicado: (2020)

Lipidomic Profiling of the Epidermis in a Mouse Model of Dermatitis Reveals Sexual Dimorphism and Changes in Lipid Composition before the Onset of Clinical Disease
por: Franco, Jackeline, et al.
Publicado: (2020)

SHARPIN Negatively Associates with TRAF2-Mediated NFκB Activation
por: Liang, Yanhua
Publicado: (2011)

Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling
por: De Franceschi, Nicola, et al.
Publicado: (2015)

Mechanism of activation of porcine dendritic cells by an α-D-glucan nanoparticle adjuvant and a nanoparticle/poly(I:C) combination adjuvant
por: Hernandez-Franco, Juan F., et al.
Publicado: (2022)

Profiling of epidermal lipids in a mouse model of dermatitis: Identification of potential biomarkers
por: Franco, Jackeline, et al.
Publicado: (2018)

Selection of a suitable reference gene for quantitative gene expression in mouse lymph nodes after vaccination
por: Mosley, Yung-Yi C., et al.
Publicado: (2017)

Intestinal colonization with Candida auris and mucosal immune response in mice treated with cefoperazone oral antibiotic
por: Das, Diprasom, et al.
Publicado: (2023)

Aluminum Adjuvants—‘Back to the Future’
por: Laera, Donatello, et al.
Publicado: (2023)

Optimizing the utilization of aluminum adjuvants in vaccines: you might just get what you want
por: HogenEsch, Harm, et al.
Publicado: (2018)

Local and Systemic Changes in Lipid Profile as Potential Biomarkers for Canine Atopic Dermatitis
por: Franco, Jackeline, et al.
Publicado: (2021)

Sharpin Contributes to TNFα Dependent NFκB Activation and Anti-Apoptotic Signalling in Hepatocytes
por: Sieber, Sabrina, et al.
Publicado: (2012)

Genetic Variation in the Magnitude and Longevity of the IgG Subclass Response to a Diphtheria-Tetanus-Acellular Pertussis (DTaP) Vaccine in Mice
por: Mosley, Yung-Yi C., et al.
Publicado: (2019)

Alpha-D-glucan nanoparticulate adjuvant induces a transient inflammatory response at the injection site and targets antigen to migratory dendritic cells
por: Lu, Fangjia, et al.
Publicado: (2017)

The Epigenetic Regulator CXXC Finger Protein 1 is Essential for Murine Hematopoiesis
por: Chun, Kristin T., et al.
Publicado: (2014)

Alpha-D-glucan-based vaccine adjuvants: Current status and future perspectives
por: Patil, Veerupaxagouda, et al.
Publicado: (2022)

SHARPIN Enhances Ferroptosis in Synovial Sarcoma Cells via NF-κB- and PRMT5-Mediated PGC1α Reduction
por: Tamiya, Hironari, et al.
Publicado: (2023)

Advances in the Structural and Physiological Functions of SHARPIN
por: Yu, Beiming, et al.
Publicado: (2022)

Formulation of a killed whole cell pneumococcus vaccine - effect of aluminum adjuvants on the antibody and IL-17 response
por: HogenEsch, Harm, et al.
Publicado: (2011)

Increased expression of Cxcr3 and its ligands, Cxcl9, and Cxcl10, during the development of alopecia areata in the mouse
por: McPhee, Caroline G., et al.
Publicado: (2012)

Porcine Circovirus type 2 (PCV2) causes apoptosis in experimentally inoculated BALB/c mice
por: Kiupel, Matti, et al.
Publicado: (2005)

Bile Acid Regulates Mononuclear Phagocytes and T Helper 17 Cells to Control Candida albicans in the Intestine
por: Datta, Abhishek, et al.
Publicado: (2022)

Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice
por: Peuhu, Emilia, et al.
Publicado: (2017)

3162 Colonization of Pregnant Women with Group B streptococcus in Latin America and Infant Outcomes
por: HogenEsch, Elena, et al.
Publicado: (2019)

An NF-κB–Dependent Role for JunB in the Induction of Proinflammatory Cytokines in LPS-Activated Bone Marrow–Derived Dendritic Cells
por: Gomard, Tiphanie, et al.
Publicado: (2010)

Specific NFκB subunit activation and kinetics of cytokine induction in adenoviral keratitis
por: Rajaiya, Jaya, et al.
Publicado: (2009)

Elevation of SIPL1 (SHARPIN) Increases Breast Cancer Risk
por: De Melo, Jason, et al.
Publicado: (2015)

SHARPIN Facilitates p53 Degradation in Breast Cancer Cells()()
por: Yang, Huijie, et al.
Publicado: (2017)

Intranasal Delivery of Inactivated Influenza Virus and Poly(I:C) Adsorbed Corn-Based Nanoparticle Vaccine Elicited Robust Antigen-Specific Cell-Mediated Immune Responses in Maternal Antibody Positive Nursery Pigs
por: Patil, Veerupaxagouda, et al.
Publicado: (2020)

Bile Acid Regulates the Colonization and Dissemination of Candida albicans from the Gastrointestinal Tract by Controlling Host Defense System and Microbiota
por: Thangamani, Shankar, et al.
Publicado: (2021)

Crystallization of SHARPIN using an automated two-dimensional grid screen for optimization
por: Stieglitz, Benjamin, et al.
Publicado: (2012)

Sharpin promotes hepatocellular carcinoma progression via transactivation of Versican expression
por: Tanaka, Y, et al.
Publicado: (2016)

Aberrant expression and high-frequency mutations of SHARPIN in nonmelanoma skin cancer
por: Zheng, Yan, et al.
Publicado: (2019)

Atrial fibrillation with rapid ventricular response as a maternal presentation of mirror syndrome: a case report
por: HogenEsch, Elena, et al.
Publicado: (2022)

NLRP3 Mediates NF-κB Activation and Cytokine Induction in Microbially Induced and Sterile Inflammation
por: Kinoshita, Takeshi, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_1dffrec4fgu89uibegq08m4qo9