C-Terminal Fluorescent Labeling Impairs Functionality of DNA Mismatch Repair Proteins

The human DNA mismatch repair (MMR) process is crucial to maintain the integrity of the genome and requires many different proteins which interact perfectly and coordinated. Germline mutations in MMR genes are responsible for the development of the hereditary form of colorectal cancer called Lynch s...

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Detalles Bibliográficos
Autores principales: Brieger, Angela, Plotz, Guido, Hinrichsen, Inga, Passmann, Sandra, Adam, Ronja, Zeuzem, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279419/
https://www.ncbi.nlm.nih.gov/pubmed/22348133
http://dx.doi.org/10.1371/journal.pone.0031863

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