Cargando…
Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental, Psychomotor, and Behavioral Development at 3 Years of Age
Background: Research suggests that prenatal phthalate exposures affect child executive function and behavior. Objective: We evaluated associations between phthalate metabolite concentrations in maternal prenatal urine and mental, motor, and behavioral development in children at 3 years of age. Metho...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Institute of Environmental Health Sciences
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279439/ https://www.ncbi.nlm.nih.gov/pubmed/21893441 http://dx.doi.org/10.1289/ehp.1103705 |
_version_ | 1782223685161058304 |
---|---|
author | Whyatt, Robin M. Liu, Xinhua Rauh, Virginia A. Calafat, Antonia M. Just, Allan C. Hoepner, Lori Diaz, Diurka Quinn, James Adibi, Jennifer Perera, Frederica P. Factor-Litvak, Pam |
author_facet | Whyatt, Robin M. Liu, Xinhua Rauh, Virginia A. Calafat, Antonia M. Just, Allan C. Hoepner, Lori Diaz, Diurka Quinn, James Adibi, Jennifer Perera, Frederica P. Factor-Litvak, Pam |
author_sort | Whyatt, Robin M. |
collection | PubMed |
description | Background: Research suggests that prenatal phthalate exposures affect child executive function and behavior. Objective: We evaluated associations between phthalate metabolite concentrations in maternal prenatal urine and mental, motor, and behavioral development in children at 3 years of age. Methods: Mono-n-butyl phthalate (MnBP), monobenzyl phthalate (MBzP), monoisobutyl phthalate (MiBP), and four di-2-ethylhexyl phthalate metabolites were measured in a spot urine sample collected from 319 women during the third trimester. When children were 3 years of age, the Mental Development Index (MDI) and Psychomotor Development Index (PDI) were measured using the Bayley Scales of Infant Development II, and behavior problems were assessed by maternal report on the Child Behavior Checklist. Results: Child PDI scores decreased with increasing log(e) MnBP [estimated adjusted β-coefficient = –2.81; 95% confidence interval (CI): –4.63, –1.0] and log(e) MiBP (β = –2.28; 95% CI: –3.90, –0.67); odds of motor delay increased significantly [per log(e) MnBP: estimated adjusted odds ratio (OR) = 1.64; 95% CI: 1.10, 2.44; per log(e) MiBP: adjusted OR =1.82; 95% CI: 1.24, 2.66]. In girls, MDI scores decreased with increasing log(e) MnBP (β = –2.67; 95% CI: –4.70, –0.65); the child sex difference in odds of mental delay was significant (p = 0.037). The ORs for clinically withdrawn behavior were 2.23 (95% CI: 1.27, 3.92) and 1.57 (95% CI: 1.07, 2.31) per log(e) unit increase in MnBP and MBzP, respectively; for clinically internalizing behaviors, the OR was 1.43 (95% CI: 1.01, 1.90) per log(e) unit increase in MBzP. Significant child sex differences were seen in associations between MnBP and MBzP and behaviors in internalizing domains (p < 0.05). Conclusion: Certain prenatal phthalate exposures may decrease child mental and motor development and increase internalizing behaviors. |
format | Online Article Text |
id | pubmed-3279439 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-32794392012-02-17 Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental, Psychomotor, and Behavioral Development at 3 Years of Age Whyatt, Robin M. Liu, Xinhua Rauh, Virginia A. Calafat, Antonia M. Just, Allan C. Hoepner, Lori Diaz, Diurka Quinn, James Adibi, Jennifer Perera, Frederica P. Factor-Litvak, Pam Environ Health Perspect Research Background: Research suggests that prenatal phthalate exposures affect child executive function and behavior. Objective: We evaluated associations between phthalate metabolite concentrations in maternal prenatal urine and mental, motor, and behavioral development in children at 3 years of age. Methods: Mono-n-butyl phthalate (MnBP), monobenzyl phthalate (MBzP), monoisobutyl phthalate (MiBP), and four di-2-ethylhexyl phthalate metabolites were measured in a spot urine sample collected from 319 women during the third trimester. When children were 3 years of age, the Mental Development Index (MDI) and Psychomotor Development Index (PDI) were measured using the Bayley Scales of Infant Development II, and behavior problems were assessed by maternal report on the Child Behavior Checklist. Results: Child PDI scores decreased with increasing log(e) MnBP [estimated adjusted β-coefficient = –2.81; 95% confidence interval (CI): –4.63, –1.0] and log(e) MiBP (β = –2.28; 95% CI: –3.90, –0.67); odds of motor delay increased significantly [per log(e) MnBP: estimated adjusted odds ratio (OR) = 1.64; 95% CI: 1.10, 2.44; per log(e) MiBP: adjusted OR =1.82; 95% CI: 1.24, 2.66]. In girls, MDI scores decreased with increasing log(e) MnBP (β = –2.67; 95% CI: –4.70, –0.65); the child sex difference in odds of mental delay was significant (p = 0.037). The ORs for clinically withdrawn behavior were 2.23 (95% CI: 1.27, 3.92) and 1.57 (95% CI: 1.07, 2.31) per log(e) unit increase in MnBP and MBzP, respectively; for clinically internalizing behaviors, the OR was 1.43 (95% CI: 1.01, 1.90) per log(e) unit increase in MBzP. Significant child sex differences were seen in associations between MnBP and MBzP and behaviors in internalizing domains (p < 0.05). Conclusion: Certain prenatal phthalate exposures may decrease child mental and motor development and increase internalizing behaviors. National Institute of Environmental Health Sciences 2011-09-06 2012-02 /pmc/articles/PMC3279439/ /pubmed/21893441 http://dx.doi.org/10.1289/ehp.1103705 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Whyatt, Robin M. Liu, Xinhua Rauh, Virginia A. Calafat, Antonia M. Just, Allan C. Hoepner, Lori Diaz, Diurka Quinn, James Adibi, Jennifer Perera, Frederica P. Factor-Litvak, Pam Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental, Psychomotor, and Behavioral Development at 3 Years of Age |
title | Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental, Psychomotor, and Behavioral Development at 3 Years of Age |
title_full | Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental, Psychomotor, and Behavioral Development at 3 Years of Age |
title_fullStr | Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental, Psychomotor, and Behavioral Development at 3 Years of Age |
title_full_unstemmed | Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental, Psychomotor, and Behavioral Development at 3 Years of Age |
title_short | Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental, Psychomotor, and Behavioral Development at 3 Years of Age |
title_sort | maternal prenatal urinary phthalate metabolite concentrations and child mental, psychomotor, and behavioral development at 3 years of age |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279439/ https://www.ncbi.nlm.nih.gov/pubmed/21893441 http://dx.doi.org/10.1289/ehp.1103705 |
work_keys_str_mv | AT whyattrobinm maternalprenatalurinaryphthalatemetaboliteconcentrationsandchildmentalpsychomotorandbehavioraldevelopmentat3yearsofage AT liuxinhua maternalprenatalurinaryphthalatemetaboliteconcentrationsandchildmentalpsychomotorandbehavioraldevelopmentat3yearsofage AT rauhvirginiaa maternalprenatalurinaryphthalatemetaboliteconcentrationsandchildmentalpsychomotorandbehavioraldevelopmentat3yearsofage AT calafatantoniam maternalprenatalurinaryphthalatemetaboliteconcentrationsandchildmentalpsychomotorandbehavioraldevelopmentat3yearsofage AT justallanc maternalprenatalurinaryphthalatemetaboliteconcentrationsandchildmentalpsychomotorandbehavioraldevelopmentat3yearsofage AT hoepnerlori maternalprenatalurinaryphthalatemetaboliteconcentrationsandchildmentalpsychomotorandbehavioraldevelopmentat3yearsofage AT diazdiurka maternalprenatalurinaryphthalatemetaboliteconcentrationsandchildmentalpsychomotorandbehavioraldevelopmentat3yearsofage AT quinnjames maternalprenatalurinaryphthalatemetaboliteconcentrationsandchildmentalpsychomotorandbehavioraldevelopmentat3yearsofage AT adibijennifer maternalprenatalurinaryphthalatemetaboliteconcentrationsandchildmentalpsychomotorandbehavioraldevelopmentat3yearsofage AT pererafredericap maternalprenatalurinaryphthalatemetaboliteconcentrationsandchildmentalpsychomotorandbehavioraldevelopmentat3yearsofage AT factorlitvakpam maternalprenatalurinaryphthalatemetaboliteconcentrationsandchildmentalpsychomotorandbehavioraldevelopmentat3yearsofage |