Cargando…

Severe Oxalosis With Systemic Manifestations

Ethylene glycol toxicity can have various clinical presentations with different organ system involvements. These presentations are independent of the level of toxicity. We describe a 31 years old male who presented with ethylene glycol toxicity manifesting as anuric renal failure who subsequently de...

Descripción completa

Detalles Bibliográficos
Autores principales: Samarneh, Majed Mark, Shtaynberg, Norbert, Goldman, Michael, Epstein, Edward, Kleiner, Morton, El-Sayegh, Suzanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279503/
https://www.ncbi.nlm.nih.gov/pubmed/22383929
http://dx.doi.org/10.4021/jocmr525w
_version_ 1782223699979534336
author Samarneh, Majed Mark
Shtaynberg, Norbert
Goldman, Michael
Epstein, Edward
Kleiner, Morton
El-Sayegh, Suzanne
author_facet Samarneh, Majed Mark
Shtaynberg, Norbert
Goldman, Michael
Epstein, Edward
Kleiner, Morton
El-Sayegh, Suzanne
author_sort Samarneh, Majed Mark
collection PubMed
description Ethylene glycol toxicity can have various clinical presentations with different organ system involvements. These presentations are independent of the level of toxicity. We describe a 31 years old male who presented with ethylene glycol toxicity manifesting as anuric renal failure who subsequently developed neurological sequela of its toxicity. Ethylene glycol is known to be metabolized to various metabolites and is ultimately converted to oxalate which results in crystal deposition the renal parenchyma causing renal failure. Oxalate deposition can occur in various organs including the nervous system as seen in our patient. The majority of patients do not recover from severe oxalosis despite the supportive care of hemodialysis in removing the parent compounds. Despite severe oxalosis, our patient was fortunate enough to be left with minimal neurological sequelae, and eventually was able to cease hemodialysis treatments. KEYWORDS: Ethylene glycol; Oxalate; Oxalosis; Glyoxylic acid
format Online
Article
Text
id pubmed-3279503
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Elmer Press
record_format MEDLINE/PubMed
spelling pubmed-32795032012-03-01 Severe Oxalosis With Systemic Manifestations Samarneh, Majed Mark Shtaynberg, Norbert Goldman, Michael Epstein, Edward Kleiner, Morton El-Sayegh, Suzanne J Clin Med Res Case Report Ethylene glycol toxicity can have various clinical presentations with different organ system involvements. These presentations are independent of the level of toxicity. We describe a 31 years old male who presented with ethylene glycol toxicity manifesting as anuric renal failure who subsequently developed neurological sequela of its toxicity. Ethylene glycol is known to be metabolized to various metabolites and is ultimately converted to oxalate which results in crystal deposition the renal parenchyma causing renal failure. Oxalate deposition can occur in various organs including the nervous system as seen in our patient. The majority of patients do not recover from severe oxalosis despite the supportive care of hemodialysis in removing the parent compounds. Despite severe oxalosis, our patient was fortunate enough to be left with minimal neurological sequelae, and eventually was able to cease hemodialysis treatments. KEYWORDS: Ethylene glycol; Oxalate; Oxalosis; Glyoxylic acid Elmer Press 2012-02 2012-01-17 /pmc/articles/PMC3279503/ /pubmed/22383929 http://dx.doi.org/10.4021/jocmr525w Text en Copyright 2012, Samarneh et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Samarneh, Majed Mark
Shtaynberg, Norbert
Goldman, Michael
Epstein, Edward
Kleiner, Morton
El-Sayegh, Suzanne
Severe Oxalosis With Systemic Manifestations
title Severe Oxalosis With Systemic Manifestations
title_full Severe Oxalosis With Systemic Manifestations
title_fullStr Severe Oxalosis With Systemic Manifestations
title_full_unstemmed Severe Oxalosis With Systemic Manifestations
title_short Severe Oxalosis With Systemic Manifestations
title_sort severe oxalosis with systemic manifestations
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279503/
https://www.ncbi.nlm.nih.gov/pubmed/22383929
http://dx.doi.org/10.4021/jocmr525w
work_keys_str_mv AT samarnehmajedmark severeoxalosiswithsystemicmanifestations
AT shtaynbergnorbert severeoxalosiswithsystemicmanifestations
AT goldmanmichael severeoxalosiswithsystemicmanifestations
AT epsteinedward severeoxalosiswithsystemicmanifestations
AT kleinermorton severeoxalosiswithsystemicmanifestations
AT elsayeghsuzanne severeoxalosiswithsystemicmanifestations