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Severe Oxalosis With Systemic Manifestations
Ethylene glycol toxicity can have various clinical presentations with different organ system involvements. These presentations are independent of the level of toxicity. We describe a 31 years old male who presented with ethylene glycol toxicity manifesting as anuric renal failure who subsequently de...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elmer Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279503/ https://www.ncbi.nlm.nih.gov/pubmed/22383929 http://dx.doi.org/10.4021/jocmr525w |
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author | Samarneh, Majed Mark Shtaynberg, Norbert Goldman, Michael Epstein, Edward Kleiner, Morton El-Sayegh, Suzanne |
author_facet | Samarneh, Majed Mark Shtaynberg, Norbert Goldman, Michael Epstein, Edward Kleiner, Morton El-Sayegh, Suzanne |
author_sort | Samarneh, Majed Mark |
collection | PubMed |
description | Ethylene glycol toxicity can have various clinical presentations with different organ system involvements. These presentations are independent of the level of toxicity. We describe a 31 years old male who presented with ethylene glycol toxicity manifesting as anuric renal failure who subsequently developed neurological sequela of its toxicity. Ethylene glycol is known to be metabolized to various metabolites and is ultimately converted to oxalate which results in crystal deposition the renal parenchyma causing renal failure. Oxalate deposition can occur in various organs including the nervous system as seen in our patient. The majority of patients do not recover from severe oxalosis despite the supportive care of hemodialysis in removing the parent compounds. Despite severe oxalosis, our patient was fortunate enough to be left with minimal neurological sequelae, and eventually was able to cease hemodialysis treatments. KEYWORDS: Ethylene glycol; Oxalate; Oxalosis; Glyoxylic acid |
format | Online Article Text |
id | pubmed-3279503 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Elmer Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-32795032012-03-01 Severe Oxalosis With Systemic Manifestations Samarneh, Majed Mark Shtaynberg, Norbert Goldman, Michael Epstein, Edward Kleiner, Morton El-Sayegh, Suzanne J Clin Med Res Case Report Ethylene glycol toxicity can have various clinical presentations with different organ system involvements. These presentations are independent of the level of toxicity. We describe a 31 years old male who presented with ethylene glycol toxicity manifesting as anuric renal failure who subsequently developed neurological sequela of its toxicity. Ethylene glycol is known to be metabolized to various metabolites and is ultimately converted to oxalate which results in crystal deposition the renal parenchyma causing renal failure. Oxalate deposition can occur in various organs including the nervous system as seen in our patient. The majority of patients do not recover from severe oxalosis despite the supportive care of hemodialysis in removing the parent compounds. Despite severe oxalosis, our patient was fortunate enough to be left with minimal neurological sequelae, and eventually was able to cease hemodialysis treatments. KEYWORDS: Ethylene glycol; Oxalate; Oxalosis; Glyoxylic acid Elmer Press 2012-02 2012-01-17 /pmc/articles/PMC3279503/ /pubmed/22383929 http://dx.doi.org/10.4021/jocmr525w Text en Copyright 2012, Samarneh et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Samarneh, Majed Mark Shtaynberg, Norbert Goldman, Michael Epstein, Edward Kleiner, Morton El-Sayegh, Suzanne Severe Oxalosis With Systemic Manifestations |
title | Severe Oxalosis With Systemic Manifestations |
title_full | Severe Oxalosis With Systemic Manifestations |
title_fullStr | Severe Oxalosis With Systemic Manifestations |
title_full_unstemmed | Severe Oxalosis With Systemic Manifestations |
title_short | Severe Oxalosis With Systemic Manifestations |
title_sort | severe oxalosis with systemic manifestations |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279503/ https://www.ncbi.nlm.nih.gov/pubmed/22383929 http://dx.doi.org/10.4021/jocmr525w |
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