Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

OBJECTIVE: It has been proposed that skeletal muscle insulin resistance arises from the accumulation of intramyocellular lipid metabolites that impede insulin signaling, including diacylglycerol and ceramide. We determined the role of de novo ceramide synthesis in mediating muscle insulin resistance...

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Detalles Bibliográficos
Autores principales: Ussher, John R., Koves, Timothy R., Cadete, Virgilio J.J., Zhang, Liyan, Jaswal, Jagdip S., Swyrd, Suzanne J., Lopaschuk, David G., Proctor, Spencer D., Keung, Wendy, Muoio, Deborah M., Lopaschuk, Gary D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279530/
https://www.ncbi.nlm.nih.gov/pubmed/20522596
http://dx.doi.org/10.2337/db09-1293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279530/
https://www.ncbi.nlm.nih.gov/pubmed/20522596
http://dx.doi.org/10.2337/db09-1293

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