Genetic and Functional Assessment of the Role of the rs13431652-A and rs573225-A Alleles in the G6PC2 Promoter That Are Strongly Associated With Elevated Fasting Glucose Levels

OBJECTIVE: Genome-wide association studies have identified a single nucleotide polymorphism (SNP), rs560887, located in a G6PC2 intron that is highly correlated with variations in fasting plasma glucose (FPG). G6PC2 encodes an islet-specific glucose-6-phosphatase catalytic subunit. This study examin...

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Detalles Bibliográficos
Autores principales: Bouatia-Naji, Nabila, Bonnefond, Amélie, Baerenwald, Devin A., Marchand, Marion, Bugliani, Marco, Marchetti, Piero, Pattou, François, Printz, Richard L., Flemming, Brian P., Umunakwe, Obi C., Conley, Nicholas L., Vaxillaire, Martine, Lantieri, Olivier, Balkau, Beverley, Marre, Michel, Lévy-Marchal, Claire, Elliott, Paul, Jarvelin, Marjo-Riitta, Meyre, David, Dina, Christian, Oeser, James K., Froguel, Philippe, O'Brien, Richard M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279535/
https://www.ncbi.nlm.nih.gov/pubmed/20622168
http://dx.doi.org/10.2337/db10-0389

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