Cargando…

Blockade of Endothelial-Mesenchymal Transition by a Smad3 Inhibitor Delays the Early Development of Streptozotocin-Induced Diabetic Nephropathy

OBJECTIVE: A multicenter, controlled trial showed that early blockade of the renin-angiotensin system in patients with type 1 diabetes and normoalbuminuria did not retard the progression of nephropathy, suggesting that other mechanism(s) are involved in the pathogenesis of early diabetic nephropathy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jinhua, Qu, Xinli, Yao, Jun, Caruana, Georgina, Ricardo, Sharon D., Yamamoto, Yasuhiko, Yamamoto, Hiroshi, Bertram, John F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Pathophysiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279546/ https://www.ncbi.nlm.nih.gov/pubmed/20682692 http://dx.doi.org/10.2337/db09-1631

Ejemplares similares

Glomerular Endothelial Cell Injury and Damage Precedes That of Podocytes in Adriamycin-Induced Nephropathy
por: Sun, Yu Bo Yang, et al.
Publicado: (2013)

NOX2 Deficiency Protects Against Streptozotocin-Induced β-Cell Destruction and Development of Diabetes in Mice
por: Xiang, Fu-Li, et al.
Publicado: (2010)

Intrarenal Dopamine Inhibits Progression of Diabetic Nephropathy
por: Zhang, Ming-Zhi, et al.
Publicado: (2012)

Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy
por: Zhou, Yuxia, et al.
Publicado: (2023)

Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy
por: Eller, Kathrin, et al.
Publicado: (2011)

The role of endothelial glycocalyx in health and disease
por: Yilmaz, Onur, et al.
Publicado: (2019)

Risk Factors Related to Inflammation and Endothelial Dysfunction in the DCCT/EDIC Cohort and Their Relationship With Nephropathy and Macrovascular Complications
por: Lopes-Virella, Maria F., et al.
Publicado: (2008)

Epidermal Growth Factor Receptor Inhibition Slows Progression of Diabetic Nephropathy in Association With a Decrease in Endoplasmic Reticulum Stress and an Increase in Autophagy
por: Zhang, Ming-Zhi, et al.
Publicado: (2014)

Effect of Endothelium-Specific Insulin Resistance on Endothelial Function In Vivo
por: Duncan, Edward R., et al.
Publicado: (2008)

Adaptation of β-Cell and Endothelial Function to Carbohydrate Loading: Influence of Insulin Resistance
por: Hurwitz, Barry E., et al.
Publicado: (2015)

Loss of ACE2 Exaggerates High-Calorie Diet–Induced Insulin Resistance by Reduction of GLUT4 in Mice
por: Takeda, Masao, et al.
Publicado: (2013)

Diabetes Irreversibly Depletes Bone Marrow–Derived Mesenchymal Progenitor Cell Subpopulations
por: Januszyk, Michael, et al.
Publicado: (2014)

Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance
por: Elias, Ivet, et al.
Publicado: (2012)

Muscle-Specific Vascular Endothelial Growth Factor Deletion Induces Muscle Capillary Rarefaction Creating Muscle Insulin Resistance
por: Bonner, Jeffrey S., et al.
Publicado: (2013)

Endothelial Fcγ Receptor IIB Activation Blunts Insulin Delivery to Skeletal Muscle to Cause Insulin Resistance in Mice
por: Tanigaki, Keiji, et al.
Publicado: (2016)

High Glucose Increases Lysyl Oxidase Expression and Activity in Retinal Endothelial Cells: Mechanism for Compromised Extracellular Matrix Barrier Function
por: Chronopoulos, Argyrios, et al.
Publicado: (2010)

Novel Role of the IGF-1 Receptor in Endothelial Function and Repair: Studies in Endothelium-Targeted IGF-1 Receptor Transgenic Mice
por: Imrie, Helen, et al.
Publicado: (2012)

Aflibercept ameliorates retinal pericyte loss and restores perfusion in streptozotocin-induced diabetic mice
por: Seo, Eoi Jong, et al.
Publicado: (2020)

The Role of MicroRNA-146a in the Pathogenesis of the Diabetic Wound-Healing Impairment: Correction With Mesenchymal Stem Cell Treatment
por: Xu, Junwang, et al.
Publicado: (2012)

Combined Blockade of Smad3 and JNK Pathways Ameliorates Progressive Fibrosis in Folic Acid Nephropathy
por: Jiang, Mengjie, et al.
Publicado: (2019)

TNF-α Signals Through PKCζ/NF-κB to Alter the Tight Junction Complex and Increase Retinal Endothelial Cell Permeability
por: Aveleira, Célia A., et al.
Publicado: (2010)

Resolvin D1 Protects Podocytes in Adriamycin-Induced Nephropathy through Modulation of 14-3-3β Acetylation
por: Zhang, Xueming, et al.
Publicado: (2013)

Stress Augments Insulin Resistance and Prothrombotic State: Role of Visceral Adipose-Derived Monocyte Chemoattractant Protein-1
por: Uchida, Yasuhiro, et al.
Publicado: (2012)

Control of Adipose Tissue Inflammation Through TRB1
por: Ostertag, Anke, et al.
Publicado: (2010)

Inflammation and Progressive Nephropathy in Type 1 Diabetes in the Diabetes Control and Complications Trial
por: Lin, Julie, et al.
Publicado: (2008)

Clinicopathological features of fast eGFR decliners among patients with diabetic nephropathy
por: Furuichi, Kengo, et al.
Publicado: (2020)

Klotho prevents epithelial–mesenchymal transition through Egr-1 downregulation in diabetic kidney disease
por: Li, Yang, et al.
Publicado: (2021)

Urinary adiponectin as a new diagnostic index for chronic kidney disease due to diabetic nephropathy
por: Yamakado, Shinnosuke, et al.
Publicado: (2019)

Microscopic hematuria is a risk factor for end-stage kidney disease in patients with biopsy-proven diabetic nephropathy
por: Okada, Sadanori, et al.
Publicado: (2020)

Variations in Risk of End-Stage Renal Disease and Risk of Mortality in an International Study of Patients With Type 1 Diabetes and Advanced Nephropathy
por: Skupien, Jan, et al.
Publicado: (2019)

Orai–vascular endothelial-cadherin signaling complex regulates high-glucose exposure-induced increased permeability of mouse aortic endothelial cells
por: Wei, Yuan, et al.
Publicado: (2021)

Circulating Levels of Adipocyte and Epidermal Fatty Acid–Binding Proteins in Relation to Nephropathy Staging and Macrovascular Complications in Type 2 Diabetic Patients
por: Yeung, Dennis C.Y., et al.
Publicado: (2009)

Relationship between diabetic nephropathy and depression: a cross-sectional analysis using the Diabetes Study from the Center of Tokyo Women's Medical University (DIACET)
por: Takasaki, Keiko, et al.
Publicado: (2016)

Declining trends of diabetic nephropathy, retinopathy and neuropathy with improving diabetes care indicators in Japanese patients with type 2 and type 1 diabetes (JDDM 46)
por: Yokoyama, Hiroki, et al.
Publicado: (2018)

Recurrence rates suggest delayed identification of plantar ulceration for patients in diabetic foot remission
por: Petersen, Brian J, et al.
Publicado: (2020)

Plasma Fetuin-A Levels and the Risk of Type 2 Diabetes
por: Stefan, Norbert, et al.
Publicado: (2008)

Distinct Monocyte Gene-Expression Profiles in Autoimmune Diabetes
por: Padmos, Roos C., et al.
Publicado: (2008)

Plasma YKL-40: A BMI-Independent Marker of Type 2 Diabetes
por: Nielsen, Anders R., et al.
Publicado: (2008)

Protein Engineering Strategies for Sustained Glucagon-Like Peptide-1 Receptor–Dependent Control of Glucose Homeostasis
por: Picha, Kristen M., et al.
Publicado: (2008)

Circulating Retinol-Binding Protein-4 Concentration Might Reflect Insulin Resistance–Associated Iron Overload
por: Fernández-Real, José Manuel, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_tvufdb3ssfs15m66enb5orjlqv