Cargando…

Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production

OBJECTIVE: The fuel sensor AMP-activated protein kinase (AMPK) in the hypothalamus regulates energy homeostasis by sensing nutritional and hormonal signals. However, the role of hypothalamic AMPK in glucose production regulation remains to be elucidated. We hypothesize that bidirectional changes in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Clair S., Lam, Carol K.L., Chari, Madhu, Cheung, Grace W.C., Kokorovic, Andrea, Gao, Sun, Leclerc, Isabelle, Rutter, Guy A., Lam, Tony K.T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279556/ https://www.ncbi.nlm.nih.gov/pubmed/20682691 http://dx.doi.org/10.2337/db10-0221

Ejemplares similares

Glucose Transporter-1 in the Hypothalamic Glial Cells Mediates Glucose Sensing to Regulate Glucose Production In Vivo
por: Chari, Madhu, et al.
Publicado: (2011)

Hypothalamic Nutrient Sensing Activates a Forebrain-Hindbrain Neuronal Circuit to Regulate Glucose Production In Vivo
por: Lam, Carol K.L., et al.
Publicado: (2011)

Hypothalamic sensing of circulating lactate regulates glucose production
por: Kokorovic, Andrea, et al.
Publicado: (2009)

Hypothalamic Protein Kinase C Regulates Glucose Production
por: Ross, Rachel, et al.
Publicado: (2008)

Duodenal PKC-δ and Cholecystokinin Signaling Axis Regulates Glucose Production
por: Breen, Danna M., et al.
Publicado: (2011)

Hypothalamic Leucine Metabolism Regulates Liver Glucose Production
por: Su, Ya, et al.
Publicado: (2012)

Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol’s Effects on Insulin Action in Rats
por: Knight, Colette M., et al.
Publicado: (2011)

Evidence for a Role of Proline and Hypothalamic Astrocytes in the Regulation of Glucose Metabolism in Rats
por: Arrieta-Cruz, Isabel, et al.
Publicado: (2013)

A glucose-sensing mechanism with glucose transporter 1 and pyruvate kinase in the area postrema regulates hepatic glucose production in rats
por: Li, Rosa J.W., et al.
Publicado: (2023)

Anorexia and Impaired Glucose Metabolism in Mice With Hypothalamic Ablation of Glut4 Neurons
por: Ren, Hongxia, et al.
Publicado: (2015)

Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons
por: Varela, Luis, et al.
Publicado: (2017)

Hypothalamic Ventromedial Lin28a Enhances Glucose Metabolism in Diet-Induced Obesity
por: Kim, Jung Dae, et al.
Publicado: (2017)

The Hypothalamic Glucagon-Like Peptide 1 Receptor Is Sufficient but Not Necessary for the Regulation of Energy Balance and Glucose Homeostasis in Mice
por: Burmeister, Melissa A., et al.
Publicado: (2017)

Hypothalamic AMP-activated Kinase Regulates Glucose-stimulated Insulin Secretion
por: Koh, Eun Hee, et al.
Publicado: (2016)

Brain Glucose Sensors Play a Significant Role in the Regulation of Pancreatic Glucose-Stimulated Insulin Secretion
por: Osundiji, Mayowa A., et al.
Publicado: (2012)

Participation of Hindbrain AMP-Activated Protein Kinase in Glucoprivic Feeding
por: Li, Ai-Jun, et al.
Publicado: (2011)

Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects
por: Swisa, Avital, et al.
Publicado: (2015)

Glucose in the hypothalamic paraventricular nucleus regulates GLP-1 release
por: Ma, Yue, et al.
Publicado: (2020)

Hypothalamic ERK Mediates the Anorectic and Thermogenic Sympathetic Effects of Leptin
por: Rahmouni, Kamal, et al.
Publicado: (2009)

Identification of Hypothalamic Glucoregulatory Neurons That Sense and Respond to Changes in Glycemia
por: Deem, Jennifer D., et al.
Publicado: (2023)

Molecular Mechanism by Which AMP-Activated Protein Kinase Activation Promotes Glycogen Accumulation in Muscle
por: Hunter, Roger W., et al.
Publicado: (2011)

Interaction of glucose sensing and leptin action in the brain
por: Li, Rosa J.W., et al.
Publicado: (2020)

AMP-Activated Protein Kinase α1 Protects Against Diet-Induced Insulin Resistance and Obesity
por: Zhang, Weiyu, et al.
Publicado: (2012)

Regulation of Hypothalamic Neuronal Sensing and Food Intake by Ketone Bodies and Fatty Acids
por: Le Foll, Christelle, et al.
Publicado: (2014)

Hypothalamic Angptl4/Fiaf Is a Novel Regulator of Food Intake and Body Weight
por: Kim, Hyun-Kyong, et al.
Publicado: (2010)

Distinct Neuronal Projections From the Hypothalamic Ventromedial Nucleus Mediate Glycemic and Behavioral Effects
por: Faber, Chelsea L., et al.
Publicado: (2018)

Hepatic Glycogen Supercompensation Activates AMP-Activated Protein Kinase, Impairs Insulin Signaling, and Reduces Glycogen Deposition in the Liver
por: Winnick, Jason J., et al.
Publicado: (2011)

Loss of AMP-Activated Protein Kinase-α2 Impairs the Insulin-Sensitizing Effect of Calorie Restriction in Skeletal Muscle
por: Wang, Pei, et al.
Publicado: (2012)

Ablation of AMP-Activated Protein Kinase α2 Activity Exacerbates Insulin Resistance Induced by High-Fat Feeding of Mice
por: Fujii, Nobuharu, et al.
Publicado: (2008)

AMP-activated Protein Kinase α2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids
por: Jelenik, Tomas, et al.
Publicado: (2010)

Hypothalamic Neuropeptide Y (NPY) Controls Hepatic VLDL-Triglyceride Secretion in Rats via the Sympathetic Nervous System
por: Bruinstroop, Eveline, et al.
Publicado: (2012)

Glucose-Induced Nuclear Shuttling of ChREBP Is Mediated by Sorcin and Ca(2+) Ions in Pancreatic β-Cells
por: Noordeen, Nafeesa A., et al.
Publicado: (2012)

Brain GLP-1 Signaling Regulates Femoral Artery Blood Flow and Insulin Sensitivity Through Hypothalamic PKC-δ
por: Cabou, Cendrine, et al.
Publicado: (2011)

Control of Blood Glucose in the Absence of Hepatic Glucose Production During Prolonged Fasting in Mice: Induction of Renal and Intestinal Gluconeogenesis by Glucagon
por: Mutel, Elodie, et al.
Publicado: (2011)

Glucose-Dependent Insulinotropic Polypeptide: A Bifunctional Glucose-Dependent Regulator of Glucagon and Insulin Secretion in Humans
por: Christensen, Mikkel, et al.
Publicado: (2011)

Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans
por: Chondronikola, Maria, et al.
Publicado: (2014)

Erratum. Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol’s Effects on Insulin Action in Rats. Diabetes 2011;60:2691–2700
por: Knight, Colette M., et al.
Publicado: (2017)

Brown Rice and Its Component, γ-Oryzanol, Attenuate the Preference for High-Fat Diet by Decreasing Hypothalamic Endoplasmic Reticulum Stress in Mice
por: Kozuka, Chisayo, et al.
Publicado: (2012)

GLUT4 Is Not Necessary for Overload-Induced Glucose Uptake or Hypertrophic Growth in Mouse Skeletal Muscle
por: McMillin, Shawna L., et al.
Publicado: (2017)

Effects of Insulin on Brain Glucose Metabolism in Impaired Glucose Tolerance
por: Hirvonen, Jussi, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_jnoe8og81dh6vma1lkskef3crf