A Central Role for Long Non-Coding RNA in Cancer

Long non-coding RNAs (ncRNAs) have been shown to regulate important biological processes that support normal cellular functions. Aberrant regulation of these essential functions can promote tumor development. In this review, we underscore the importance of the regulatory role played by this distinct...

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Detalles Bibliográficos
Autores principales: Mitra, Sheetal A., Mitra, Anirban P., Triche, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279698/
https://www.ncbi.nlm.nih.gov/pubmed/22363342
http://dx.doi.org/10.3389/fgene.2012.00017
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author Mitra, Sheetal A.
Mitra, Anirban P.
Triche, Timothy J.
author_facet Mitra, Sheetal A.
Mitra, Anirban P.
Triche, Timothy J.
author_sort Mitra, Sheetal A.
collection PubMed
description Long non-coding RNAs (ncRNAs) have been shown to regulate important biological processes that support normal cellular functions. Aberrant regulation of these essential functions can promote tumor development. In this review, we underscore the importance of the regulatory role played by this distinct class of ncRNAs in cancer-associated pathways that govern mechanisms such as cell growth, invasion, and metastasis. We also highlight the possibility of using these unique RNAs as diagnostic and prognostic biomarkers in malignancies.
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spelling pubmed-32796982012-02-23 A Central Role for Long Non-Coding RNA in Cancer Mitra, Sheetal A. Mitra, Anirban P. Triche, Timothy J. Front Genet Genetics Long non-coding RNAs (ncRNAs) have been shown to regulate important biological processes that support normal cellular functions. Aberrant regulation of these essential functions can promote tumor development. In this review, we underscore the importance of the regulatory role played by this distinct class of ncRNAs in cancer-associated pathways that govern mechanisms such as cell growth, invasion, and metastasis. We also highlight the possibility of using these unique RNAs as diagnostic and prognostic biomarkers in malignancies. Frontiers Research Foundation 2012-02-15 /pmc/articles/PMC3279698/ /pubmed/22363342 http://dx.doi.org/10.3389/fgene.2012.00017 Text en Copyright © 2012 Mitra, Mitra and Triche. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Genetics
Mitra, Sheetal A.
Mitra, Anirban P.
Triche, Timothy J.
A Central Role for Long Non-Coding RNA in Cancer
title A Central Role for Long Non-Coding RNA in Cancer
title_full A Central Role for Long Non-Coding RNA in Cancer
title_fullStr A Central Role for Long Non-Coding RNA in Cancer
title_full_unstemmed A Central Role for Long Non-Coding RNA in Cancer
title_short A Central Role for Long Non-Coding RNA in Cancer
title_sort central role for long non-coding rna in cancer
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279698/
https://www.ncbi.nlm.nih.gov/pubmed/22363342
http://dx.doi.org/10.3389/fgene.2012.00017
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