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11β-Hydroxysteroid Dehydrogenase Type 1, But Not Type 2, Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice

Glucocorticoids profoundly influence immune responses, and synthetic glucocorticoids are widely used clinically for their potent antiinflammatory effects. Endogenous glucocorticoid action is modulated by the two isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD). In vivo, 11β-HSD1 catalyzes the...

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Detalles Bibliográficos
Autores principales:	Coutinho, Agnes E., Gray, Mohini, Brownstein, David G., Salter, Donald M., Sawatzky, Deborah A., Clay, Spike, Gilmour, James S., Seckl, Jonathan R., Savill, John S., Chapman, Karen E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Endocrine Society 2012
Materias:	Glucocorticoids-CRH-ACTH-Adrenal
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279737/ https://www.ncbi.nlm.nih.gov/pubmed/22067318 http://dx.doi.org/10.1210/en.2011-1398

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