Cargando…

Sensitivity pattern of methicillin resistant Staphylococcus aureus isolated from patients admitted in a tertiary care hospital of Pakistan

BACKGROUND AND OBJECTIVES: Methicillin resistant Staphylococcus aureus (MRSA) is a major nosocomial pathogen causing significant morbidity and mortality. The aim of this study was to evaluate in vitro activities of different antibiotics against methicillin resistant Staphylococcus aureus. MATERIALS...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaleem, F, Usman, J, Hassan, A, Omair, M, Khalid, A, Uddin, Roz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279784/
https://www.ncbi.nlm.nih.gov/pubmed/22347563
_version_ 1782223734976806912
author Kaleem, F
Usman, J
Hassan, A
Omair, M
Khalid, A
Uddin, Roz
author_facet Kaleem, F
Usman, J
Hassan, A
Omair, M
Khalid, A
Uddin, Roz
author_sort Kaleem, F
collection PubMed
description BACKGROUND AND OBJECTIVES: Methicillin resistant Staphylococcus aureus (MRSA) is a major nosocomial pathogen causing significant morbidity and mortality. The aim of this study was to evaluate in vitro activities of different antibiotics against methicillin resistant Staphylococcus aureus. MATERIALS AND METHOD: The study was conducted over a period of one year (January 2009 – December 2009) in the Department of Microbiology, Army Medical College, the National University of Sciences and Technology, Pakistan. One hundred and thirty-nine Methicillin resistant Staphylococcus aureus isolated from the clinical specimens at Rawalpindi Military Hospital were subjected to in vitro susceptibility against various antimicrobials using Kirby Bauer disc diffusion technique. RESULTS: All the isolated MRSA organisms were uniformly susceptible to vancomycin, linezolid and tigecycline. Other drugs which were found to be effective were chloramphenicol, and rifampacin. Most of the MRSA were isolated from pus samples. CONCLUSION: Vancomycin, tigecycline and linezolid were effective against methicillin resistant strains of S.aureus. This study suggests that chloramphenicol and rifampacin also have good in vitro efficacy for methicillin resistant S. aureus infections. Oral dosing option for linezolid, chloramphenicol and rifampacin can allow earlier discharge of hospitalized patients and thus reduce health care expenses as well as help reduce the chances of vancomycin resistant strains emergence.
format Online
Article
Text
id pubmed-3279784
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Tehran University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-32797842012-02-16 Sensitivity pattern of methicillin resistant Staphylococcus aureus isolated from patients admitted in a tertiary care hospital of Pakistan Kaleem, F Usman, J Hassan, A Omair, M Khalid, A Uddin, Roz Iran J Microbiol Original Article BACKGROUND AND OBJECTIVES: Methicillin resistant Staphylococcus aureus (MRSA) is a major nosocomial pathogen causing significant morbidity and mortality. The aim of this study was to evaluate in vitro activities of different antibiotics against methicillin resistant Staphylococcus aureus. MATERIALS AND METHOD: The study was conducted over a period of one year (January 2009 – December 2009) in the Department of Microbiology, Army Medical College, the National University of Sciences and Technology, Pakistan. One hundred and thirty-nine Methicillin resistant Staphylococcus aureus isolated from the clinical specimens at Rawalpindi Military Hospital were subjected to in vitro susceptibility against various antimicrobials using Kirby Bauer disc diffusion technique. RESULTS: All the isolated MRSA organisms were uniformly susceptible to vancomycin, linezolid and tigecycline. Other drugs which were found to be effective were chloramphenicol, and rifampacin. Most of the MRSA were isolated from pus samples. CONCLUSION: Vancomycin, tigecycline and linezolid were effective against methicillin resistant strains of S.aureus. This study suggests that chloramphenicol and rifampacin also have good in vitro efficacy for methicillin resistant S. aureus infections. Oral dosing option for linezolid, chloramphenicol and rifampacin can allow earlier discharge of hospitalized patients and thus reduce health care expenses as well as help reduce the chances of vancomycin resistant strains emergence. Tehran University of Medical Sciences 2010-09 /pmc/articles/PMC3279784/ /pubmed/22347563 Text en © 2010 Iranian Society of Microbiology & Tehran University of Medical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kaleem, F
Usman, J
Hassan, A
Omair, M
Khalid, A
Uddin, Roz
Sensitivity pattern of methicillin resistant Staphylococcus aureus isolated from patients admitted in a tertiary care hospital of Pakistan
title Sensitivity pattern of methicillin resistant Staphylococcus aureus isolated from patients admitted in a tertiary care hospital of Pakistan
title_full Sensitivity pattern of methicillin resistant Staphylococcus aureus isolated from patients admitted in a tertiary care hospital of Pakistan
title_fullStr Sensitivity pattern of methicillin resistant Staphylococcus aureus isolated from patients admitted in a tertiary care hospital of Pakistan
title_full_unstemmed Sensitivity pattern of methicillin resistant Staphylococcus aureus isolated from patients admitted in a tertiary care hospital of Pakistan
title_short Sensitivity pattern of methicillin resistant Staphylococcus aureus isolated from patients admitted in a tertiary care hospital of Pakistan
title_sort sensitivity pattern of methicillin resistant staphylococcus aureus isolated from patients admitted in a tertiary care hospital of pakistan
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279784/
https://www.ncbi.nlm.nih.gov/pubmed/22347563
work_keys_str_mv AT kaleemf sensitivitypatternofmethicillinresistantstaphylococcusaureusisolatedfrompatientsadmittedinatertiarycarehospitalofpakistan
AT usmanj sensitivitypatternofmethicillinresistantstaphylococcusaureusisolatedfrompatientsadmittedinatertiarycarehospitalofpakistan
AT hassana sensitivitypatternofmethicillinresistantstaphylococcusaureusisolatedfrompatientsadmittedinatertiarycarehospitalofpakistan
AT omairm sensitivitypatternofmethicillinresistantstaphylococcusaureusisolatedfrompatientsadmittedinatertiarycarehospitalofpakistan
AT khalida sensitivitypatternofmethicillinresistantstaphylococcusaureusisolatedfrompatientsadmittedinatertiarycarehospitalofpakistan
AT uddinroz sensitivitypatternofmethicillinresistantstaphylococcusaureusisolatedfrompatientsadmittedinatertiarycarehospitalofpakistan