Toxoplasma Infection in Schizophrenia Patients: A Comparative Study with Control Group

BACKGROUND: Schizophrenia is a serious, chronic, and often debilitating neuropsychiatric disorder. Its causes are still poorly understood. Besides genetic and non-genetic (environmental) factors are thought to be important as the cause of the structural and functional deficits that characterize schi...

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Autores principales: Alipour, A, Shojaee, S, Mohebali, M, Tehranidoost, M, Abdi Masoleh, F, Keshavarz, H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279881/
https://www.ncbi.nlm.nih.gov/pubmed/22347285
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author Alipour, A
Shojaee, S
Mohebali, M
Tehranidoost, M
Abdi Masoleh, F
Keshavarz, H
author_facet Alipour, A
Shojaee, S
Mohebali, M
Tehranidoost, M
Abdi Masoleh, F
Keshavarz, H
author_sort Alipour, A
collection PubMed
description BACKGROUND: Schizophrenia is a serious, chronic, and often debilitating neuropsychiatric disorder. Its causes are still poorly understood. Besides genetic and non-genetic (environmental) factors are thought to be important as the cause of the structural and functional deficits that characterize schizophrenia. This study aimed to compare Toxoplasma gondii infection between schizophrenia patients and non-schizophrenia individuals as control group. METHODS: A case-control study was designed in Tehran, Iran during 2009-2010. Sixty-two patients with schizophrenia and 62 non-schizophrenia volunteers were selected. To ascertain a possible relationship between T. gondii infection and schizophrenia, anti-Toxoplasma IgG antibodies were detected by indirect-ELISA. Data were statistically analyzed by chi- square at a confidence level of 99%. RESULTS: The sero-positivity rate among patients with schizophrenia (67.7%) was significantly higher than control group (37.1) (P <0. 01). CONCLUSION: A significant correlation between Toxoplasma infection and schizophrenia might be expected.
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spelling pubmed-32798812012-02-16 Toxoplasma Infection in Schizophrenia Patients: A Comparative Study with Control Group Alipour, A Shojaee, S Mohebali, M Tehranidoost, M Abdi Masoleh, F Keshavarz, H Iran J Parasitol Original Article BACKGROUND: Schizophrenia is a serious, chronic, and often debilitating neuropsychiatric disorder. Its causes are still poorly understood. Besides genetic and non-genetic (environmental) factors are thought to be important as the cause of the structural and functional deficits that characterize schizophrenia. This study aimed to compare Toxoplasma gondii infection between schizophrenia patients and non-schizophrenia individuals as control group. METHODS: A case-control study was designed in Tehran, Iran during 2009-2010. Sixty-two patients with schizophrenia and 62 non-schizophrenia volunteers were selected. To ascertain a possible relationship between T. gondii infection and schizophrenia, anti-Toxoplasma IgG antibodies were detected by indirect-ELISA. Data were statistically analyzed by chi- square at a confidence level of 99%. RESULTS: The sero-positivity rate among patients with schizophrenia (67.7%) was significantly higher than control group (37.1) (P <0. 01). CONCLUSION: A significant correlation between Toxoplasma infection and schizophrenia might be expected. Tehran University of Medical Sciences 2011-06 /pmc/articles/PMC3279881/ /pubmed/22347285 Text en © 2011 Iranian Society of Parasitology & Tehran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Alipour, A
Shojaee, S
Mohebali, M
Tehranidoost, M
Abdi Masoleh, F
Keshavarz, H
Toxoplasma Infection in Schizophrenia Patients: A Comparative Study with Control Group
title Toxoplasma Infection in Schizophrenia Patients: A Comparative Study with Control Group
title_full Toxoplasma Infection in Schizophrenia Patients: A Comparative Study with Control Group
title_fullStr Toxoplasma Infection in Schizophrenia Patients: A Comparative Study with Control Group
title_full_unstemmed Toxoplasma Infection in Schizophrenia Patients: A Comparative Study with Control Group
title_short Toxoplasma Infection in Schizophrenia Patients: A Comparative Study with Control Group
title_sort toxoplasma infection in schizophrenia patients: a comparative study with control group
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279881/
https://www.ncbi.nlm.nih.gov/pubmed/22347285
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