Cargando…

Structure Based Discovery of Small Molecules to Regulate the Activity of Human Insulin Degrading Enzyme

BACKGROUND: Insulin-degrading enzyme (IDE) is an allosteric Zn(+2) metalloprotease involved in the degradation of many peptides including amyloid-β, and insulin that play key roles in Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM), respectively. Therefore, the use of therapeutic a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Çakir, Bilal, Dağliyan, Onur, Dağyildiz, Ezgi, Bariş, İbrahim, Kavakli, Ibrahim Halil, Kizilel, Seda, Türkay, Metin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280214/ https://www.ncbi.nlm.nih.gov/pubmed/22355395 http://dx.doi.org/10.1371/journal.pone.0031787

Ejemplares similares

Optimization Based Tumor Classification from Microarray Gene Expression Data
por: Dagliyan, Onur, et al.
Publicado: (2011)

Investigation of Real-Time Photorepair Activity on DNA via Surface Plasmon Resonance
por: Kizilel, Rıza, et al.
Publicado: (2012)

Correction: Investigation of Real-Time Photorepair Activity on DNA via Surface Plasmon Resonance
por: Kizilel, Rıza, et al.
Publicado: (2012)

Structure-based design and classifications of small molecules regulating the circadian rhythm period
por: Gul, Seref, et al.
Publicado: (2021)

Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice
por: Gul, Seref, et al.
Publicado: (2022)

Classification of drug molecules considering their IC(50 )values using mixed-integer linear programming based hyper-boxes method
por: Armutlu, Pelin, et al.
Publicado: (2008)

Investigation of the Interaction between the Large and Small Subunits of Potato ADP-Glucose Pyrophosphorylase
por: Barıs, Ibrahim, et al.
Publicado: (2009)

The secondary pocket of cryptochrome 2 is important for the regulation of its stability and localization
por: Parlak, Gizem Cagla, et al.
Publicado: (2022)

The crystal structure of Vibrio cholerae (6-4) photolyase reveals interactions with cofactors and a DNA-binding region
por: Cakilkaya, Baris, et al.
Publicado: (2022)

Identification of two Amino Acids in the C-terminal Domain of Mouse CRY2 Essential for PER2 Interaction
por: Ozber, Natali, et al.
Publicado: (2010)

No Major Role for Insulin-Degrading Enzyme in Antigen Presentation by MHC Molecules
por: Culina, Slobodan, et al.
Publicado: (2014)

Small-Molecule Activators of Insulin-Degrading Enzyme Discovered through High-Throughput Compound Screening
por: Cabrol, Christelle, et al.
Publicado: (2009)

Redox Regulation of Insulin Degradation by Insulin-Degrading Enzyme
por: Cordes, Crystal M., et al.
Publicado: (2011)

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice
por: Deprez-Poulain, Rebecca, et al.
Publicado: (2015)

Anti-icing Properties on Surfaces through a Functional Composite: Effect of Ionic Salts
por: Aydin, Derya, et al.
Publicado: (2018)

Neovascularization of engineered tissues for clinical translation: Where we are, where we should be?
por: Nazeer, Muhammad Anwaar, et al.
Publicado: (2021)

P2X7 receptor antagonist delivery vehicle based on photocrosslinked amphiphilic hybrid gels
por: Aydin, Derya, et al.
Publicado: (2018)

Targeting Insulin-Degrading Enzyme in Insulin Clearance
por: Leissring, Malcolm A., et al.
Publicado: (2021)

Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme
por: González-Casimiro, Carlos M., et al.
Publicado: (2021)

Nanoparticle and Gelation Stabilized Functional Composites of an Ionic Salt in a Hydrophobic Polymer Matrix
por: Kanyas, Selin, et al.
Publicado: (2014)

MerR and ChrR mediate blue light induced photo-oxidative stress response at the transcriptional level in Vibrio cholerae
por: Tardu, Mehmet, et al.
Publicado: (2017)

Inhibition of Insulin Degrading Enzyme and Insulin Degradation by UV-Killed Lactobacillus acidophilus
por: Neyazi, Nadia, et al.
Publicado: (2018)

Insulin-Degrading Enzyme: Paradoxes and Possibilities
por: Leissring, Malcolm A.
Publicado: (2021)

Discovery of carbamate degrading enzymes by functional metagenomics
por: Ufarté, Lisa, et al.
Publicado: (2017)

Discovery of small-molecule enzyme activators by activity-based protein profiling
por: Kok, Bernard P., et al.
Publicado: (2020)

Centriolar satellites are required for efficient ciliogenesis and ciliary content regulation
por: Odabasi, Ezgi, et al.
Publicado: (2019)

High‐Yield Production of Biohybrid Microalgae for On‐Demand Cargo Delivery
por: Akolpoglu, Mukrime Birgul, et al.
Publicado: (2020)

Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme
por: Zheng, Qiuchen, et al.
Publicado: (2021)

Molecular Aspects of Circadian Pharmacology and Relevance for Cancer Chronotherapy
por: Ozturk, Narin, et al.
Publicado: (2017)

Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme
por: Zhang, Zhening, et al.
Publicado: (2018)

Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin
por: Leissring, Malcolm A., et al.
Publicado: (2010)

The insulin-degrading enzyme as a link between insulin and neuropeptides metabolism
por: Wacławczyk, Dorota, et al.
Publicado: (2021)

Diurnal Changes in Capecitabine Clock-Controlled Metabolism Enzymes Are Responsible for Its Pharmacokinetics in Male Mice
por: Akyel, Yasemin Kubra, et al.
Publicado: (2023)

Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme
por: Ivancic, Valerie A., et al.
Publicado: (2018)

An Extended Polyanion Activation Surface in Insulin Degrading Enzyme
por: Song, Eun Suk, et al.
Publicado: (2015)

Insulin-degrading enzyme is not secreted from cultured cells
por: Song, Eun Suk, et al.
Publicado: (2018)

Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme
por: Distefano, Alessia, et al.
Publicado: (2022)

Effects of Microbial Transglutaminase on Physicochemical, Microbial and Sensorial Properties of Kefir Produced by Using Mixture Cow’s and Soymilk
por: Temiz, Hasan, et al.
Publicado: (2017)

The Role of Insulin, Insulin Growth Factor, and Insulin-Degrading Enzyme in Brain Aging and Alzheimer's Disease
por: Messier, Claude, et al.
Publicado: (2005)

Neck circumference cut-off points for detecting overweight and obesity among school children in Northern Cyprus
por: Turkay, Ezgi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fd6hle1h8v35uv5mr0mfg9daqt