Large Aggregates Are the Major Soluble Aβ Species in AD Brain Fractionated with Density Gradient Ultracentrifugation

Soluble amyloid-β (Aβ) aggregates of various sizes, ranging from dimers to large protofibrils, have been associated with neurotoxicity and synaptic dysfunction in Alzheimer's Disease (AD). To investigate the properties of biologically relevant Aβ species, brain extracts from amyloid β protein p...

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Detalles Bibliográficos
Autores principales: Sehlin, Dag, Englund, Hillevi, Simu, Barbro, Karlsson, Mikael, Ingelsson, Martin, Nikolajeff, Fredrik, Lannfelt, Lars, Pettersson, Frida Ekholm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280222/
https://www.ncbi.nlm.nih.gov/pubmed/22355408
http://dx.doi.org/10.1371/journal.pone.0032014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280222/
https://www.ncbi.nlm.nih.gov/pubmed/22355408
http://dx.doi.org/10.1371/journal.pone.0032014

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