Charged and Hydrophobic Surfaces on the A Chain of Shiga-Like Toxin 1 Recognize the C-Terminal Domain of Ribosomal Stalk Proteins

Shiga-like toxins are ribosome-inactivating proteins (RIP) produced by pathogenic E. coli strains that are responsible for hemorrhagic colitis and hemolytic uremic syndrome. The catalytic A(1) chain of Shiga-like toxin 1 (SLT-1), a representative RIP, first docks onto a conserved peptide SD[D/E]DMGF...

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Detalles Bibliográficos
Autores principales: McCluskey, Andrew J., Bolewska-Pedyczak, Eleonora, Jarvik, Nick, Chen, Gang, Sidhu, Sachdev S., Gariépy, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280276/
https://www.ncbi.nlm.nih.gov/pubmed/22355345
http://dx.doi.org/10.1371/journal.pone.0031191

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