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Changes in Striatal Dopamine Release Associated with Human Motor-Skill Acquisition

The acquisition of new motor skills is essential throughout daily life and involves the processes of learning new motor sequence and encoding elementary aspects of new movement. Although previous animal studies have suggested a functional importance for striatal dopamine release in the learning of n...

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Autores principales: Kawashima, Shoji, Ueki, Yoshino, Kato, Takashi, Matsukawa, Noriyuki, Mima, Tatsuya, Hallett, Mark, Ito, Kengo, Ojika, Kosei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280327/
https://www.ncbi.nlm.nih.gov/pubmed/22355391
http://dx.doi.org/10.1371/journal.pone.0031728
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author Kawashima, Shoji
Ueki, Yoshino
Kato, Takashi
Matsukawa, Noriyuki
Mima, Tatsuya
Hallett, Mark
Ito, Kengo
Ojika, Kosei
author_facet Kawashima, Shoji
Ueki, Yoshino
Kato, Takashi
Matsukawa, Noriyuki
Mima, Tatsuya
Hallett, Mark
Ito, Kengo
Ojika, Kosei
author_sort Kawashima, Shoji
collection PubMed
description The acquisition of new motor skills is essential throughout daily life and involves the processes of learning new motor sequence and encoding elementary aspects of new movement. Although previous animal studies have suggested a functional importance for striatal dopamine release in the learning of new motor sequence, its role in encoding elementary aspects of new movement has not yet been investigated. To elucidate this, we investigated changes in striatal dopamine levels during initial skill-training (Day 1) compared with acquired conditions (Day 2) using (11)C-raclopride positron-emission tomography. Ten volunteers learned to perform brisk contractions using their non-dominant left thumbs with the aid of visual feedback. On Day 1, the mean acceleration of each session was improved through repeated training sessions until performance neared asymptotic levels, while improved motor performance was retained from the beginning on Day 2. The (11)C-raclopride binding potential (BP) in the right putamen was reduced during initial skill-training compared with under acquired conditions. Moreover, voxel-wise analysis revealed that (11)C-raclopride BP was particularly reduced in the right antero-dorsal to the lateral part of the putamen. Based on findings from previous fMRI studies that show a gradual shift of activation within the striatum during the initial processing of motor learning, striatal dopamine may play a role in the dynamic cortico-striatal activation during encoding of new motor memory in skill acquisition.
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spelling pubmed-32803272012-02-21 Changes in Striatal Dopamine Release Associated with Human Motor-Skill Acquisition Kawashima, Shoji Ueki, Yoshino Kato, Takashi Matsukawa, Noriyuki Mima, Tatsuya Hallett, Mark Ito, Kengo Ojika, Kosei PLoS One Research Article The acquisition of new motor skills is essential throughout daily life and involves the processes of learning new motor sequence and encoding elementary aspects of new movement. Although previous animal studies have suggested a functional importance for striatal dopamine release in the learning of new motor sequence, its role in encoding elementary aspects of new movement has not yet been investigated. To elucidate this, we investigated changes in striatal dopamine levels during initial skill-training (Day 1) compared with acquired conditions (Day 2) using (11)C-raclopride positron-emission tomography. Ten volunteers learned to perform brisk contractions using their non-dominant left thumbs with the aid of visual feedback. On Day 1, the mean acceleration of each session was improved through repeated training sessions until performance neared asymptotic levels, while improved motor performance was retained from the beginning on Day 2. The (11)C-raclopride binding potential (BP) in the right putamen was reduced during initial skill-training compared with under acquired conditions. Moreover, voxel-wise analysis revealed that (11)C-raclopride BP was particularly reduced in the right antero-dorsal to the lateral part of the putamen. Based on findings from previous fMRI studies that show a gradual shift of activation within the striatum during the initial processing of motor learning, striatal dopamine may play a role in the dynamic cortico-striatal activation during encoding of new motor memory in skill acquisition. Public Library of Science 2012-02-15 /pmc/articles/PMC3280327/ /pubmed/22355391 http://dx.doi.org/10.1371/journal.pone.0031728 Text en Kawashima et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kawashima, Shoji
Ueki, Yoshino
Kato, Takashi
Matsukawa, Noriyuki
Mima, Tatsuya
Hallett, Mark
Ito, Kengo
Ojika, Kosei
Changes in Striatal Dopamine Release Associated with Human Motor-Skill Acquisition
title Changes in Striatal Dopamine Release Associated with Human Motor-Skill Acquisition
title_full Changes in Striatal Dopamine Release Associated with Human Motor-Skill Acquisition
title_fullStr Changes in Striatal Dopamine Release Associated with Human Motor-Skill Acquisition
title_full_unstemmed Changes in Striatal Dopamine Release Associated with Human Motor-Skill Acquisition
title_short Changes in Striatal Dopamine Release Associated with Human Motor-Skill Acquisition
title_sort changes in striatal dopamine release associated with human motor-skill acquisition
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280327/
https://www.ncbi.nlm.nih.gov/pubmed/22355391
http://dx.doi.org/10.1371/journal.pone.0031728
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