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Establishment of a Novel Fluorescence-Based Method to Evaluate Chaperone-Mediated Autophagy in a Single Neuron

BACKGROUND: Chaperone-mediated autophagy (CMA) is a selective autophagy-lysosome protein degradation pathway. The role of CMA in normal neuronal functions and in neural disease pathogenesis remains unclear, in part because there is no available method to monitor CMA activity at the single-cell level...

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Detalles Bibliográficos
Autores principales:	Seki, Takahiro, Yoshino, Ken-ich, Tanaka, Shigeru, Dohi, Eisuke, Onji, Tomoya, Yamamoto, Kazuhiro, Hide, Izumi, Paulson, Henry L., Saito, Naoaki, Sakai, Norio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280339/ https://www.ncbi.nlm.nih.gov/pubmed/22363588 http://dx.doi.org/10.1371/journal.pone.0031232

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