Aurantoside K, a New Antifungal Tetramic Acid Glycoside from a Fijian Marine Sponge of the Genus Melophlus

A new tetramic acid glycoside, aurantoside K, was isolated from a marine sponge belonging to the genus Melophlus. The structure of the compound was elucidated on the basis of spectroscopic analysis ((1)H NMR, (1)H–(1)H COSY, HSQC, and HMBC, as well as high-resolution ESILCMS). Aurantoside K did not...

Descripción completa

Detalles Bibliográficos
Autores principales: Kumar, Rohitesh, Subramani, Ramesh, Feussner, Klaus-D., Aalbersberg, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280539/
https://www.ncbi.nlm.nih.gov/pubmed/22363230
http://dx.doi.org/10.3390/md10010200
Descripción
Sumario:A new tetramic acid glycoside, aurantoside K, was isolated from a marine sponge belonging to the genus Melophlus. The structure of the compound was elucidated on the basis of spectroscopic analysis ((1)H NMR, (1)H–(1)H COSY, HSQC, and HMBC, as well as high-resolution ESILCMS). Aurantoside K did not show any significant activity in antimalarial, antibacterial, or HCT-116 cytotoxicity assays, but exhibited a wide spectrum of antifungal activity against wild type Candida albicans, amphotericin-resistant C. albicans, Cryptococcus neoformans, Aspergillus niger, Penicillium sp., Rhizopus sporangia and Sordaria sp.

Ejemplares similares