Aurantoside K, a New Antifungal Tetramic Acid Glycoside from a Fijian Marine Sponge of the Genus Melophlus

A new tetramic acid glycoside, aurantoside K, was isolated from a marine sponge belonging to the genus Melophlus. The structure of the compound was elucidated on the basis of spectroscopic analysis ((1)H NMR, (1)H–(1)H COSY, HSQC, and HMBC, as well as high-resolution ESILCMS). Aurantoside K did not...

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Autores principales: Kumar, Rohitesh, Subramani, Ramesh, Feussner, Klaus-D., Aalbersberg, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280539/
https://www.ncbi.nlm.nih.gov/pubmed/22363230
http://dx.doi.org/10.3390/md10010200
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author Kumar, Rohitesh
Subramani, Ramesh
Feussner, Klaus-D.
Aalbersberg, William
author_facet Kumar, Rohitesh
Subramani, Ramesh
Feussner, Klaus-D.
Aalbersberg, William
author_sort Kumar, Rohitesh
collection PubMed
description A new tetramic acid glycoside, aurantoside K, was isolated from a marine sponge belonging to the genus Melophlus. The structure of the compound was elucidated on the basis of spectroscopic analysis ((1)H NMR, (1)H–(1)H COSY, HSQC, and HMBC, as well as high-resolution ESILCMS). Aurantoside K did not show any significant activity in antimalarial, antibacterial, or HCT-116 cytotoxicity assays, but exhibited a wide spectrum of antifungal activity against wild type Candida albicans, amphotericin-resistant C. albicans, Cryptococcus neoformans, Aspergillus niger, Penicillium sp., Rhizopus sporangia and Sordaria sp.
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spelling pubmed-32805392012-02-23 Aurantoside K, a New Antifungal Tetramic Acid Glycoside from a Fijian Marine Sponge of the Genus Melophlus Kumar, Rohitesh Subramani, Ramesh Feussner, Klaus-D. Aalbersberg, William Mar Drugs Article A new tetramic acid glycoside, aurantoside K, was isolated from a marine sponge belonging to the genus Melophlus. The structure of the compound was elucidated on the basis of spectroscopic analysis ((1)H NMR, (1)H–(1)H COSY, HSQC, and HMBC, as well as high-resolution ESILCMS). Aurantoside K did not show any significant activity in antimalarial, antibacterial, or HCT-116 cytotoxicity assays, but exhibited a wide spectrum of antifungal activity against wild type Candida albicans, amphotericin-resistant C. albicans, Cryptococcus neoformans, Aspergillus niger, Penicillium sp., Rhizopus sporangia and Sordaria sp. MDPI 2012-01-18 /pmc/articles/PMC3280539/ /pubmed/22363230 http://dx.doi.org/10.3390/md10010200 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Kumar, Rohitesh
Subramani, Ramesh
Feussner, Klaus-D.
Aalbersberg, William
Aurantoside K, a New Antifungal Tetramic Acid Glycoside from a Fijian Marine Sponge of the Genus Melophlus
title Aurantoside K, a New Antifungal Tetramic Acid Glycoside from a Fijian Marine Sponge of the Genus Melophlus
title_full Aurantoside K, a New Antifungal Tetramic Acid Glycoside from a Fijian Marine Sponge of the Genus Melophlus
title_fullStr Aurantoside K, a New Antifungal Tetramic Acid Glycoside from a Fijian Marine Sponge of the Genus Melophlus
title_full_unstemmed Aurantoside K, a New Antifungal Tetramic Acid Glycoside from a Fijian Marine Sponge of the Genus Melophlus
title_short Aurantoside K, a New Antifungal Tetramic Acid Glycoside from a Fijian Marine Sponge of the Genus Melophlus
title_sort aurantoside k, a new antifungal tetramic acid glycoside from a fijian marine sponge of the genus melophlus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280539/
https://www.ncbi.nlm.nih.gov/pubmed/22363230
http://dx.doi.org/10.3390/md10010200
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