Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum

Chemical investigation of the Dongsha Atoll soft coral Lobophytum crassum has afforded four new cembranoids, crassumols A–C (1–3) and 13-acetoxysarcophytoxide (4). The structures of these isolated compounds were elucidated by extensive NMR and HRESIMS experiments. The cytotoxicity and anti-HCMV (Hum...

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Autores principales: Lin, Shih-Tseng, Wang, Shang-Kwei, Duh, Chang-Yih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280576/
https://www.ncbi.nlm.nih.gov/pubmed/22363246
http://dx.doi.org/10.3390/md9122705
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author Lin, Shih-Tseng
Wang, Shang-Kwei
Duh, Chang-Yih
author_facet Lin, Shih-Tseng
Wang, Shang-Kwei
Duh, Chang-Yih
author_sort Lin, Shih-Tseng
collection PubMed
description Chemical investigation of the Dongsha Atoll soft coral Lobophytum crassum has afforded four new cembranoids, crassumols A–C (1–3) and 13-acetoxysarcophytoxide (4). The structures of these isolated compounds were elucidated by extensive NMR and HRESIMS experiments. The cytotoxicity and anti-HCMV (Human cytomegalovirus) activities of 1–4 were evaluated in vitro. Compound 4 exhibited cytotoxicity against A-549 (human lung carcinoma) cell line with an ED(50) of 3.6 μg/mL.
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spelling pubmed-32805762012-02-23 Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum Lin, Shih-Tseng Wang, Shang-Kwei Duh, Chang-Yih Mar Drugs Article Chemical investigation of the Dongsha Atoll soft coral Lobophytum crassum has afforded four new cembranoids, crassumols A–C (1–3) and 13-acetoxysarcophytoxide (4). The structures of these isolated compounds were elucidated by extensive NMR and HRESIMS experiments. The cytotoxicity and anti-HCMV (Human cytomegalovirus) activities of 1–4 were evaluated in vitro. Compound 4 exhibited cytotoxicity against A-549 (human lung carcinoma) cell line with an ED(50) of 3.6 μg/mL. MDPI 2011-12-15 /pmc/articles/PMC3280576/ /pubmed/22363246 http://dx.doi.org/10.3390/md9122705 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Lin, Shih-Tseng
Wang, Shang-Kwei
Duh, Chang-Yih
Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum
title Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum
title_full Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum
title_fullStr Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum
title_full_unstemmed Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum
title_short Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum
title_sort cembranoids from the dongsha atoll soft coral lobophytum crassum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280576/
https://www.ncbi.nlm.nih.gov/pubmed/22363246
http://dx.doi.org/10.3390/md9122705
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AT wangshangkwei cembranoidsfromthedongshaatollsoftcorallobophytumcrassum
AT duhchangyih cembranoidsfromthedongshaatollsoftcorallobophytumcrassum

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