Tetrahydrofuran Cembranoids from the Cultured Soft Coral Lobophytum crassum

Three new cembranoids, culobophylins A–C (1–3), along with two known compounds (4 and 5) were isolated from the cultured soft coral Lobophytum crassum. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analog...

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Autores principales: Lee, Nai-Lun, Su, Jui-Hsin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280583/
https://www.ncbi.nlm.nih.gov/pubmed/22363238
http://dx.doi.org/10.3390/md9122526
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author Lee, Nai-Lun
Su, Jui-Hsin
author_facet Lee, Nai-Lun
Su, Jui-Hsin
author_sort Lee, Nai-Lun
collection PubMed
description Three new cembranoids, culobophylins A–C (1–3), along with two known compounds (4 and 5) were isolated from the cultured soft coral Lobophytum crassum. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Among these metabolites, 2 is rarely found in cembranoids possessing an isopropyl moiety with an epoxide group. Compound 1 exhibited significant cytotoxic activity against HL60 and DLD-1 cancer cell lines.
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spelling pubmed-32805832012-02-23 Tetrahydrofuran Cembranoids from the Cultured Soft Coral Lobophytum crassum Lee, Nai-Lun Su, Jui-Hsin Mar Drugs Article Three new cembranoids, culobophylins A–C (1–3), along with two known compounds (4 and 5) were isolated from the cultured soft coral Lobophytum crassum. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Among these metabolites, 2 is rarely found in cembranoids possessing an isopropyl moiety with an epoxide group. Compound 1 exhibited significant cytotoxic activity against HL60 and DLD-1 cancer cell lines. MDPI 2011-12-07 /pmc/articles/PMC3280583/ /pubmed/22363238 http://dx.doi.org/10.3390/md9122526 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Lee, Nai-Lun
Su, Jui-Hsin
Tetrahydrofuran Cembranoids from the Cultured Soft Coral Lobophytum crassum
title Tetrahydrofuran Cembranoids from the Cultured Soft Coral Lobophytum crassum
title_full Tetrahydrofuran Cembranoids from the Cultured Soft Coral Lobophytum crassum
title_fullStr Tetrahydrofuran Cembranoids from the Cultured Soft Coral Lobophytum crassum
title_full_unstemmed Tetrahydrofuran Cembranoids from the Cultured Soft Coral Lobophytum crassum
title_short Tetrahydrofuran Cembranoids from the Cultured Soft Coral Lobophytum crassum
title_sort tetrahydrofuran cembranoids from the cultured soft coral lobophytum crassum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280583/
https://www.ncbi.nlm.nih.gov/pubmed/22363238
http://dx.doi.org/10.3390/md9122526
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AT sujuihsin tetrahydrofurancembranoidsfromtheculturedsoftcorallobophytumcrassum

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