Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity

Naturally occurring nucleotide modifications within RNA have been proposed to be structural determinants for innate immune recognition. We tested this hypothesis in the context of native nonself-RNAs. Isolated, fully modified native bacterial transfer RNAs (tRNAs) induced significant secretion of IF...

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Detalles Bibliográficos
Autores principales: Gehrig, Stefanie, Eberle, Mariel-Esther, Botschen, Flavia, Rimbach, Katharina, Eberle, Florian, Eigenbrod, Tatjana, Kaiser, Steffen, Holmes, Walter M., Erdmann, Volker A., Sprinzl, Mathias, Bec, Guillaume, Keith, Gérard, Dalpke, Alexander H., Helm, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280868/
https://www.ncbi.nlm.nih.gov/pubmed/22312113
http://dx.doi.org/10.1084/jem.20111044

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