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The 2′-O-methylation status of a single guanosine controls transfer RNA–mediated Toll-like receptor 7 activation or inhibition

Foreign RNA serves as pathogen-associated molecular pattern (PAMP) and is a potent immune stimulator for innate immune receptors. However, the role of single bacterial RNA species in immune activation has not been characterized in detail. We analyzed the immunostimulatory potential of transfer RNA (...

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Detalles Bibliográficos
Autores principales:	Jöckel, Stefanie, Nees, Gernot, Sommer, Romy, Zhao, Yang, Cherkasov, Dmitry, Hori, Hiroyuki, Ehm, Gundi, Schnare, Markus, Nain, Marianne, Kaufmann, Andreas, Bauer, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280869/ https://www.ncbi.nlm.nih.gov/pubmed/22312111 http://dx.doi.org/10.1084/jem.20111075

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