Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression

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Intracellular macrophage migration inhibitory factor (MIF) often becomes stabilized in human cancer cells. MIF can promote tumor cell survival, and elevated MIF protein correlates with tumor aggressiveness and poor prognosis. However, the molecular mechanism facilitating MIF stabilization in tumors...

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Detalles Bibliográficos
Autores principales: Schulz, Ramona, Marchenko, Natalia D., Holembowski, Lena, Fingerle-Rowson, Günter, Pesic, Marina, Zender, Lars, Dobbelstein, Matthias, Moll, Ute M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280870/
https://www.ncbi.nlm.nih.gov/pubmed/22271573
http://dx.doi.org/10.1084/jem.20111117
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