Self-reactive human CD4 T cell clones form unusual immunological synapses

Recognition of self–peptide-MHC (pMHC) complexes by CD4 T cells plays an important role in the pathogenesis of many autoimmune diseases. We analyzed formation of immunological synapses (IS) in self-reactive T cell clones from patients with multiple sclerosis and type 1 diabetes. All self-reactive T...

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Detalles Bibliográficos
Autores principales: Schubert, David A., Gordo, Susana, Sabatino, Joseph J., Vardhana, Santosh, Gagnon, Etienne, Sethi, Dhruv K., Seth, Nilufer P., Choudhuri, Kaushik, Reijonen, Helena, Nepom, Gerald T., Evavold, Brian D., Dustin, Michael L., Wucherpfennig, Kai W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280872/
https://www.ncbi.nlm.nih.gov/pubmed/22312112
http://dx.doi.org/10.1084/jem.20111485

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