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Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

The development of cancer-specific therapeutics has been limited because most healthy cells and cancer cells depend on common pathways. Pyruvate kinase (PK) exists in M1 (PKM1) and M2 (PKM2) isoforms. PKM2, whose expression in cancer cells results in aerobic glycolysis and is suggested to bestow a s...

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Detalles Bibliográficos
Autores principales:	Goldberg, Michael S., Sharp, Phillip A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280873/ https://www.ncbi.nlm.nih.gov/pubmed/22271574 http://dx.doi.org/10.1084/jem.20111487

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