Sequential class switching is required for the generation of high affinity IgE antibodies

IgE antibodies with high affinity for their antigens can be stably cross-linked at low concentrations by trace amounts of antigen, whereas IgE antibodies with low affinity bind their antigens weakly. In this study, we find that there are two distinct pathways to generate high and low affinity IgE. H...

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Detalles Bibliográficos
Autores principales: Xiong, Huizhong, Dolpady, Jayashree, Wabl, Matthias, Curotto de Lafaille, Maria A., Lafaille, Juan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280879/
https://www.ncbi.nlm.nih.gov/pubmed/22249450
http://dx.doi.org/10.1084/jem.20111941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280879/
https://www.ncbi.nlm.nih.gov/pubmed/22249450
http://dx.doi.org/10.1084/jem.20111941

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